Online detector for sevoflurane in blood, and applications thereof
A sevoflurane and detector technology, applied in instruments, measuring devices, scientific instruments, etc., can solve problems such as long time consumption, and achieve the effects of less consumables, low operating costs, and fast detection speed
Inactive Publication Date: 2017-05-10
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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Problems solved by technology
The detection of halothane anesthetics in blood is based on the fact that blood is a complex biological sample, and sample pretreatment must be performed before chromatogr
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Embodiment 1
[0032] Push 40uL of blood sevoflurane samples of different concentrations (1ppm, 10ppm, 100ppm) in the blood catheter, and use the device of the present invention to detect the obtained ion mobility spectrum. The migration time of sevoflurane anesthetic was 12.62ms.
Embodiment 2
[0034]Push 40 uL of blood isoflurane samples of different concentrations (1ppm, 10ppm, 100ppm) in the blood catheter, and use the device of the present invention to detect the obtained ion mobility spectrum. The migration time of isoflurane anesthetic was 12.32ms.
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The present invention provides an online detector for sevoflurane in blood, wherein an ion mobility spectroscopy technology is adopted as a basic detection technology, sample thermal analysis and headspace sampling technology are combined, blood sample pretreatment is not required, and the continuous intraoperative online detection of sevoflurane in human blood is achieved. According to the present invention, the method has advantages of simpleness, rapidness, high efficiency, and good reliability.
Description
technical field [0001] The invention designs an online sevoflurane detector in blood based on ion mobility spectrometry technology, combined with sample thermal analysis and headspace sampling technology. The detection device and method in the present invention can be widely used in clinical drug administration depth analysis, and guide clinicians to use drugs accurately. Background technique [0002] Sevoflurane is an inhalational anesthetic. The chemical name of sevoflurane is fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether; molecular formula: C4H3F7O; molecular weight: 200.06. Sevoflurane is indicated for the induction and maintenance of general anesthesia for in-hospital and outpatient procedures in adult and pediatric patients. The induction dose must be individualized and adjusted as required by the patient's age and clinical condition. Clinically, when the concentration of 2% to 4% is used to induce anesthesia and maintain it at 3%, the blood drug concen...
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Inventor 李海洋李恩有王新张融鞠帮玉王爱博
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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