Absolute blood volume measurement using ultrafiltration pulsing

A pulse and blood volume technology, used in blood filtration, diagnostic recording/measurement, applications, etc.

Active Publication Date: 2017-05-10
FRESENIUS MEDICAL CARE HLDG INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] While IDH features in much of the discussion surrounding blood volume in dialysis patients, knowledge of absolute blood volume is likely to have other important consequences in this population

Method used

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  • Absolute blood volume measurement using ultrafiltration pulsing
  • Absolute blood volume measurement using ultrafiltration pulsing
  • Absolute blood volume measurement using ultrafiltration pulsing

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Embodiment Construction

[0037] Fundamental factors of acute circulatory regulation

[0038] Cycle regulation is complex and only some basic aspects are discussed below. Broadly speaking, the purpose of blood circulation is to deliver oxygen and nutrients to tissues, remove carbon dioxide and other metabolic waste products from tissues, and distribute humoral transmitters throughout the body. Blood flow through various tissues is governed by the respective metabolic needs of these tissues, but arterial blood pressure and cardiac output are necessary for blood flow (ie, circulation) to exist under all conditions. Arterial blood pressure is itself a function of cardiac output and the total peripheral resistance of the vascular system. Thus, there are three interrelated parameters that characterize the state of the circulatory system: cardiac output, arterial blood pressure, and total peripheral resistance, which are related as follows:

[0039] Cardiac output = mean arterial pressure / total peripheral ...

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Abstract

The importance of absolute blood volume in hemodialysis patients is illustrated, the acute physiologic mechanisms involved in the preservation of adequate circulation during ultrafiltration are summarized, and the reasons why hemodialysis patients are often particularly vulnerable to reductions in blood volume are outlined. The shortcomings of relative blood volume measurements are also discussed, and a case is made for the superiority of absolute blood volume measurements. A mathematical concept is introduced that allows relative blood volume devices to be used for the estimation of absolute blood volume. Finally, the implications of absolute blood volume beyond intradialytic hypotension are discussed and a paradigm shift in the approach to dry weight attainment is proposed.

Description

[0001] related application [0002] This application claims the benefit of US Provisional Application No. 62 / 000,667, filed May 20, 2014. The entire teachings of the aforementioned applications are incorporated herein by reference. Background technique [0003] There are hundreds of thousands of hemodialysis patients in the United States. At a rate of three treatments per week, this amounts to millions of hemodialysis treatments per year. Intradialytic hypotension (IDH) remains the most common complication during dialysis treatment, with a frequency of approximately 15% to 30% (and possibly higher) of all maintenance hemodialysis settings. This is a large number, which is largely a function of current hemodialysis practice (i.e., relatively short (3-4 hours), infrequent (3 times a week) sessions during which fluid cumulative need to be corrected) results. Other aspects (eg, intradialysis sodium load through abnormally high dialysate sodium concentration or inappropriate u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00A61B5/0205A61B5/145A61M1/34A61M1/36G06F19/00
CPCA61M1/3403A61M1/361A61M1/3612A61B5/02A61B5/02028A61B5/0205A61B5/14542A61B5/6866A61M2230/207G16H20/40
Inventor F·卡佩尔S·蒂伊森D·H·福尔廷格P·科坦科
Owner FRESENIUS MEDICAL CARE HLDG INC
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