Thymine derivatives and quinazoline-dione derivatives for the inhibition of hsp27

A technology of thymine and derivatives, which is applied in the direction of sugar derivatives, medical preparations containing active ingredients, and compounds of Group 5/15 elements of the periodic table, etc., which can solve the problem of no antibacterial concentration value and no compound active substance concentration Numerical issues
CN107074791AInactive Publication Date: 2017-08-18DRESDEN UNIVERSITY OF TECHNOLOGY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DRESDEN UNIVERSITY OF TECHNOLOGY
Publication Date
2017-08-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to novel HSP27 inhibitors, in particular thymine derivatives according to general formula (VI), (VII) or (VII) and phenothiazine derivatives according to formula (V), and to their use as drugs for the selective inhibition of the heat shock protein HSP27 (HSPB1), in particular for use in the treatment of carcinomas or cystic fibrosis, said inhibitors having a particularly advantageous activity in the lower micromolar or sub-micromolar active ingredient concentration range with respect to HSP27.
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Description

technical field

[0001] The present invention relates to a novel thymine derivative and its application as medicine for selective inhibition of heat shock protein HSP27 (HSPB1). Background technique

[0002] For some cancers, the treatment with cytostatics will not be effective from the beginning. Even if the patient suffers from an easily curable cancer type, the treatment with cytostatics may fail after a period of time. One possible reason is the development of resistance, whereby tumor cells become less sensitive to cytostatics, the biological processes behind which are known.

[0003] It can be seen that the treatment of various tumor cell lines with cytostatics leads to an increase in the expression of cellular proteins, which has a great impact on the protection and stability of the correct folding of receptors, enzymes and cellular structural proteins.

[0004] Heat shock protein is an evolutionarily highly conserved protein formed by cells under sublethal stress con...

Claims

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