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Application of silymarin in relieving of reproductive toxicity of zeranol in animal corn

A technology for zearalenone and reproductive toxicity, which is applied in the application field of silymarin in alleviating the reproductive toxicity of zearalenone in animals, can solve the problem that the application of ZEN reproductive toxicity antidote has not been reported, and achieve the effect of relieving reproductive toxicity. Effect

Active Publication Date: 2017-08-29
HUAZHONG AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Silymarin has been included in the drug list by the FDA as a nutrient and a drug for the treatment of ingested liver toxicity, but its application in animals as an antidote for ZEN reproductive toxicity has not been reported

Method used

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  • Application of silymarin in relieving of reproductive toxicity of zeranol in animal corn
  • Application of silymarin in relieving of reproductive toxicity of zeranol in animal corn
  • Application of silymarin in relieving of reproductive toxicity of zeranol in animal corn

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1 Comparative experiment of dietary silymarin added curative effect (the following experiments focus on the reproductive toxicity and detoxification function effect of silymarin used in the rat zearalenone poisoning model)

[0016] 1. Animal experiment design and administration:

[0017] Sixty SPF grade SD rats with similar body weights were weaned on the 21st, and they were randomly divided into 5 groups, 12 in each group. Rats were fed in polyethylene plastic mouse cages, with 2 rats per cage. They were fed with basal diet, ZEN added to the basal diet, and silymarin with different concentration gradients: 100mg / kg, 200mg / kg, 500mg / kg. The test period is 6 weeks.

[0018] Table 1 Test grouping and treatment

[0019]

[0020] 2. Detection indicators:

[0021] 1) Determination of growth performance

[0022] Weigh on an empty stomach before the experiment, record the initial weight, weigh on an empty stomach before execution, record the final body weight, ...

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Abstract

The invention discloses application of silymarin in relieving of the reproductive toxicity of zeranol in animal corn. The silymarin is added into feed at the addition amount of 100 to 500mg / kg. By means of the silymarin, a reproductive toxicity effect caused by ZEN can be effectively relieved.

Description

technical field [0001] The invention relates to a new application of silymarin, in particular to an application of silymarin in alleviating the reproductive toxicity of animal zearalenone. Background technique [0002] Zearalenone (Zearalenone, referred to as ZEN), also known as F-2 toxin, is a non-steroidal mycotoxin with estrogenic activity mainly produced by Fusarium graminearum, widely present in moldy corn, sorghum, Cereal crops such as wheat and milk. In 2009, the mycotoxin contamination test results of 90 feed and raw material samples from all over the country showed that the positive detection rate of ZEN in corn samples was as high as 84.6%, and the ZEN content in positive samples was as high as 229mg / kg (Zhang Cheng, 2009). [0003] ZEN has the effect of estrogen, and its main action site on animals is the reproductive system. It can induce estrogen hyperactivity in domestic animals, poultry and experimental mice. Animals (including humans) are in pregnancy. If t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/357A61P39/02A61P15/00A23K20/121
CPCA61K31/357A23K20/121
Inventor 孙铝辉张妮娅齐德生高鑫赵玲
Owner HUAZHONG AGRI UNIV
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