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Application of ripterol and its derivatives in the preparation of products for the prevention and/or treatment of fatty liver

A fatty liver and product technology, applied in the field of biomedicine, can solve problems such as lack of effective treatment methods, and achieve the effect of reducing hepatic steatosis

Active Publication Date: 2019-08-30
JIANGSU MEIDISEN BIOLOGICAL MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Commonly used drugs are mainly aimed at lowering blood lipids and protecting liver cells, and there is a lack of effective treatments that directly act on liver lipid deposition

Method used

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  • Application of ripterol and its derivatives in the preparation of products for the prevention and/or treatment of fatty liver
  • Application of ripterol and its derivatives in the preparation of products for the prevention and/or treatment of fatty liver
  • Application of ripterol and its derivatives in the preparation of products for the prevention and/or treatment of fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0035] The pharmacodynamic experiment of embodiment ripterol

[0036] Twenty-two male SD rats (6 weeks old) were purchased from the SPF Experimental Animal Center. After one week of adaptive feeding, the test was started. The rats were divided into three groups according to body weight. Among them, the normal diet control group was given 10% fat content feed, and the high-fat diet group and the medication group were both given 45% fat content feed. At 8 weeks, the high-fat diet group had already experienced significant weight gain ( figure 1 ), the normal diet control group and the high-fat diet group were administered with DMSO by gavage, and the medication group was administered with ripterol 3.6mg / kg / day. (Rat feed was purchased from Jiangsu Medison Biomedical Co., Ltd., and Riproterol was purchased from Toronto Research Chemicals Inc). Weighed at 12 weeks and the results were as follows figure 1 shown.

[0037] figure 1 It is a comparison chart of body weight changes ...

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Abstract

The invention discloses reproterol and novel application of its derivatives in the preparation of products for preventing and / or treating fatty liver. Experiments prove that by treating a fatty liver model rat with reproterol, it is possible to significantly relieve hepatic fatty degeneration, relieve hepatic lipid droplet accumulation and decrease the content of hepatic triglyceride. The reproterol is significant to the prevention and / or treatment of fatty liver.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the new application of ripterol and its derivatives, in particular to the application of ripterol and its derivatives in the preparation of products for the prevention and / or treatment of fatty liver. Background technique [0002] Reproterol is a selective bronchial smooth muscle β2 receptor agonist, currently used clinically for the treatment of bronchial asthma and asthmatic bronchitis. Its bronchodilation effect is stronger than that of meta-hydroxyisoproterenol, and it is well tolerated. It takes effect 30 minutes after oral administration, and lasts for 4-6 hours. It has little effect on heart rate, cardiac output and blood pressure. Therapeutic effects in liver diseases have not been reported yet. [0003] Fatty liver refers to the pathological changes caused by excessive accumulation of fat in liver cells due to various reasons. When the fat content exceeds 5% of the wet weight o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/522A61P1/16A23L33/10
Inventor 管又飞杨永亮张晓燕王冰苏文
Owner JIANGSU MEIDISEN BIOLOGICAL MEDICINE
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