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Chitosan anti-tumor hydrogel and application

A hydrogel and anti-tumor technology, applied in the direction of anti-tumor drugs, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of high toxicity and side effects, low chemotherapy targeting efficiency, etc., to achieve Good biocompatibility, the effect of preventing burst release

Inactive Publication Date: 2017-11-17
江苏海乔生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the problems of low targeting efficiency and high toxic and side effects of current chemotherapy, the present invention provides a chitosan-based anti-tumor hydrogel, which is obtained by reacting a cross-linking agent with chitosan and loading anti-tumor drugs

Method used

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  • Chitosan anti-tumor hydrogel and application
  • Chitosan anti-tumor hydrogel and application
  • Chitosan anti-tumor hydrogel and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take 5 chitosan solutions with a volume concentration of 0.03g / mL, add 4 volume concentrations of 0.125g / mL cross-linking agent solution (polyethylene glycol di-4-aldehyde benzoate), 1 volume concentration is 40mg / mL of doxorubicin aqueous solution, mixed and reacted at room temperature for 0.5min to obtain an anti-tumor hydrogel.

Embodiment 2

[0022] Take 1 chitosan solution with volume concentration of 0.03g / mL, add 4 volume concentrations of cross-linking agent solution (polyethylene glycol di-4-formylbenzoate) with volume concentration of 0.125g / mL, and 1 volume concentration is 20mg / mL mL of doxorubicin aqueous solution was mixed and reacted at room temperature for 0.5 min to obtain an anti-tumor hydrogel.

Embodiment 3

[0024] Take 1 chitosan solution with a volume concentration of 0.03g / mL, add 4 volume concentrations of a crosslinking agent solution with a volume concentration of 0.125g / mL, and 1 volume concentration of adriamycin aqueous solution with a volume concentration of 10mg / mL, and mix and react at room temperature for 0.5min , to obtain anti-tumor hydrogels.

[0025] The hydrogel samples prepared in the above embodiments can realize the transition from high-dose drug to low-dose drug, and treat tumors at different stages.

[0026] The hydrogel has the feature of being injectable, and the anti-tumor hydrogel is directly implanted into the body through injection to realize minimally invasive tumor treatment.

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Abstract

The invention relates to chitosan anti-tumor hydrogel and application. The chitosan anti-tumor hydrogel is obtained by reaction of water-soluble chitosan, a crosslinking agent and water-soluble anti-tumor medicine. According to the chitosan anti-tumor hydrogel, safety is high, the effect of tumor inhibition is obvious, the intensity of the hydrogel can be adjusted according to required releasing time, meanwhile, the chitosan anti-tumor hydrogel has a certain bacteria resistance and bacteria inhibition characteristics, and local infection of implantation can be effectively prevented.

Description

technical field [0001] The invention belongs to the technical field of biological materials and hydrogel preparation, and relates to a chitosan anti-tumor hydrogel and an application thereof. Background technique [0002] Chemotherapy is widely used in primary tumor treatment as a treatment modality. However, traditional chemotherapy via intravenous injection has disadvantages such as low drug delivery efficiency, high toxicity, and the need for multiple injections. In recent years, intratumoral injection, as a new way of tumor treatment, has received extensive attention from scientific researchers. Intratumoral injection refers to the direct injection of anticancer drugs into the tumor, avoiding the dilution of the drug due to the long circulation in the body and reducing the impact of the drug on normal tissues. Injecting the solution of anti-tumor drugs directly at the tumor site cannot effectively improve the administration efficiency, reduce toxicity and reduce inject...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/704A61K47/36A61K47/14A61P35/00
CPCA61K9/0002A61K9/0024A61K9/06A61K31/704A61K47/14A61K47/36
Inventor 陶磊王兴王婵彬
Owner 江苏海乔生物科技有限公司
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