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Amyloid Beta fibril-decomposing agent, therapeutic/prophylactic agent for disease associated with amyloid Beta fibrillogenesis, and food composition for treating/preventing disease associated with amyloid Beta fibrillogenesis

A technology for the decomposition of amyloid protein and fiber, which is applied in the direction of drug combination, food ingredients containing inorganic compounds, metabolic diseases, etc.

Active Publication Date: 2017-11-28
WELL STONE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] However, there have been no reports of prevention / treatment of Alzheimer's disease using earthworms so far.

Method used

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  • Amyloid Beta fibril-decomposing agent, therapeutic/prophylactic agent for disease associated with amyloid Beta fibrillogenesis, and food composition for treating/preventing disease associated with amyloid Beta fibrillogenesis
  • Amyloid Beta fibril-decomposing agent, therapeutic/prophylactic agent for disease associated with amyloid Beta fibrillogenesis, and food composition for treating/preventing disease associated with amyloid Beta fibrillogenesis
  • Amyloid Beta fibril-decomposing agent, therapeutic/prophylactic agent for disease associated with amyloid Beta fibrillogenesis, and food composition for treating/preventing disease associated with amyloid Beta fibrillogenesis

Examples

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Embodiment

[0084] Hereinafter, the present invention will be described in further detail through examples. The present invention is not limited in any way by the following examples. It should be noted that the following "%" are all mass benchmarks unless otherwise specified.

[0085] [Preparation of earthworm dry powder]

[0086] After being placed in a bright place for 24 hours, 30 kg of live red earthworms peeled off the dirt attached to the epidermis are spread on a flat plate to a thickness of about 5 cm, and 250 g of sodium chloride is evenly sprinkled on it. After 20 minutes the earthworms were washed with water. Thereafter, 250 g of citric acid was sprinkled similarly, and 30 liters of pure water was added and diluted for 15 seconds. At this time, the pH immediately after adding water was 2.25, and the pH at the time of complete dilution was 2.74. When sprinkled with citric acid powder, the earthworms release a yellow body fluid all at once. After diluting with water, keep it...

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Abstract

The purpose of the present invention is to provide: an amyloid Beta fibril-decomposing agent which contains a naturally occurring substance as an active ingredient; a therapeutic or prophylactic agent for a disease associated with amyloid Beta fibrillogenesis; and a food composition for treating or preventing a disease associated with amyloid Beta fibrillogenesis. An amyloid Beta fibril-decomposing agent which contains, as an active ingredient, a dried powder, a milled product and / or an extract of an earthworm; a therapeutic or prophylactic agent for a disease associated with amyloid Beta fibrillogenesis; and a food composition for treating or preventing a disease associated with amyloid Beta fibrillogenesis. The disease associated with amyloid Beta fibrillogenesis is preferably Alzheimer's disease.

Description

technical field [0001] The present invention relates to a β-amyloid fibril decomposing agent, a therapeutic agent / preventive agent, and a therapeutic / preventive food composition for a disease caused by β-amyloid fibrillation. Background technique [0002] β-amyloid (also called amyloid-β protein or amyloid-β peptide) is known as a protein comprising about 40 residues of amino acids, and in the brains of Alzheimer's patients, β-amyloid aggregates and Accumulation of fibrotic amyloid beta fibers. β-amyloid is a water-soluble protein that is released outside the cell. It itself does not show toxicity to nerve cells, but it produces toxicity to nerve cells through the formation of β-amyloid fibers (for example, Patent Document 1). Therefore, it is considered that β-amyloid fibers The accumulation of Alzheimer's is one of the causes of Alzheimer's disease. [0003] The main molecular species known as β-amyloid are β-amyloid 40 with Val at the C-terminal formed by 40 residues an...

Claims

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Application Information

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IPC IPC(8): A61K35/62A23L33/10A61P3/00A61P25/28
CPCA23L33/10A61K35/62A61P25/28A23V2200/322A23V2002/00A23L35/00A23L3/44A23V2250/16A23V2250/1614A23V2250/161A23V2300/18A61K9/14
Inventor 石井阳一冈本猛石井纱也香
Owner WELL STONE
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