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30 results about "Fibrillogenesis" patented technology

Fibrillogenesis is the development of fine fibrils normally present in collagen fibers of connective tissue. It is derived from the Greek fibrillo (meaning fibrils, or pertaining to fibrils) and genesis (to create, the process by which something is created).

Inhibitors and disassemblers of fibrillogenesis

InactiveUS20030130484A1Highly effective at disassembling pre-formed fibrilsInhibition formationPeptide/protein ingredientsPeptide preparation methodsFiberAmino acid
Methods and compositions are presented that inhibit fibril formation and / or bring about disassembly of pre-formed fibrils. Compositions include peptides with short beta-strands with two faces: one that can bind to beta-amyloids through hydrogen bonds, and one which blocks propagation of hydrogen bonding needed to form fibrils. Thus, short congeners of the fibril protein containing N-methyl amino acids or esters are provided for the inhibition of fibril formation and for the disassembly of pre-existing or pre-formed fibrils. Specific aspects address beta-amyloid fibrils; prion mediated fibrils; Huntington protein fibrils. Methods for screening for potential fibril inhibitors and disassemblers, diagnostic analysis and treatments are provided.
Owner:UNIVERSITY OF CHICAGO

Methods of investigating, diagnosing, and treating amyloidosis

InactiveUS20020019335A1Constant level of amyloid depositsEffective preventionNervous disorderPeptide/protein ingredientsAA amyloidosisAssay
The present invention provides a therapeutic method for removing amyloid fibrils from a patient. The present invention also provides a transgenic animal that develops systemic AA amyloidosis within three weeks for use as a tool to investigate AA amyloidosis and to evaluate agents that may be potentially useful in preventing and treating amyloid-related disorders. Further, the present invention provides diagnostic assays for monitoring immunoglobulin light chain fibrillogenesis in real-time and for identification of the chemical nature of the protein in amyloid deposits which enables the determination of the type of amyloidosis for therapeutic and prognostic purposes.
Owner:UNIV OF TENNESSEE RES FOUND

Peptides for the treatment of Alzheimer's disease and other beta-amyloid protein fibrillogenesis disorders

InactiveUS6933280B2Enhance clearance and removalConnective tissue peptidesNervous disorderAβ amyloidMedicine
A pharmaceutical composition, or pharmaceutical agent for treating Aβ amyloidosis in a patient, having at least one selected laminin peptide or fragment thereof from the group AG73 (SEQ ID NO:1), C-16 (SEQ ID NO:2), A-13 (SEQ ID NO:3), HA3G47 (SEQ ID NO:4), HA3G58 (SEQ ID NO:5), HA3G67 (SEQ ID NO:6), HA3G74 (SEQ ID NO:7), HA3G76 (SEQ ID NO:8), HA3G79 (SEQ ID NO:9), HA3G83 (SEQ ID NO:10), A4G82 (SEQ ID NO:11), A5G15 (SEQ ID NO:12), A5G56 (SEQ ID NO:13), A5G80 (SEQ ID NO:14), A5G81 (SEQ ID NO:15), A5G82 (SEQ ID NO: 16), A5G84 (SEQ ID NO:17), A5G101 (SEQ ID NO:18), and A5G109 (SEQ ID NO:19) (Sequence Group A); and a method for enhancing Aβ amyloid fibril formation, or of forming amyloid-plaque like deposits in vitro, including incubating Aβ 1-40 or Aβ 1-42 with a selected laminin-derived polypeptide from the group A-13 (SEQ ID NO:3), HA3G47 (SEQ ID NO:4), HA3G58 (SEQ ID NO:5), HA3G83 (SEQ ID NO:10), LAM-L (SEQ ID NO:20), A4G10 SEQ ID NO:21), A4G46 (SEQ ID NO:22), A4G47 (SEQ ID NO:23), A4G84 (SEQ ID NO:24), A4G92 (SEQ ID NO:25), A4G107 (SEQ ID NO:26), A5G3 (SEQ ID NO:27), A5G10 (SEQ ID NO:28), A5G27 (SEQ ID NO:29), A5G33 (SEQ ID NO:30), A5G65 (SEQ ID NO:31), A5G77 (SEQ ID NO:32), A5G87 (SEQ ID NO:33), A5G90 (SEQ ID NO:34) and A5G111 (SEQ ID NO:35) (Sequence Group C).
Owner:UNIV OF WASHINGTON

Mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and structural templates

Transthyretin (TTR), a tetrameric thyroxine (T4) carrier protein, is associated with a variety of amyloid diseases. Derivative of biphenyl ethers (BPE), which are shown to interact with a high affinity to its T4 binding site thereby preventing its aggregation and fibrillogenesis. They prevent fibrillogenesis by stabilizing the tetrameric ground state of transthyretin. Two compounds (2-(5-mercapto-[1,3,4]oxadiazol-2-yl)-phenol and 2,3,6-trichloro-N-(4H-[1,2,4]triazol-3-yl) exhibit the ability to arrest TTR amyloidosis. The dissociation constants for the binding of BPEs and compound 11 and 12 to TTR correlate with their efficacies of inhibiting amyloidosis. They also have the ability to inhibit the elongation of intermediate fibrils as well as show nearly complete (>90%) disruption of the preformed fibrils. Biphenyl ethers and compounds 11 and 12 as very potent inhibitors of TTR fibrillization and inducible cytotoxicity.
Owner:NATIONAL INSTUTUTE OF IMMUNOLOGY

Cathechins for the Treatment of Fibrillogenesis in Alzheimer's Disease, Parkinson's Disease, Systemic AA Amyloidosis, and Other Amyloid Disorders

InactiveUS20080306143A1Promote mental acuityReduce and reverse age associated cognitiveBiocideNervous disorderAA amyloidosisMammal
A method of treating an amyloid disease, or a disease characterized by alpha-synuclein or NAC fibrillogenesis, in a mammalian subject. The method includes administering to the mammal a therapeutically effective amount of a various disclosed catechins or green tea extract. A pharmaceutical composition comprising a therapeutically effective amount of a catechin and a pharmaceutically acceptable excipient. The therapeutic amount of the catechin or green tea extract is selected for efficacy in treating amyloid, alpha-synuclein or NAC fibrillogenesis in a mammalian subject.
Owner:COGNITIVE CLARITY INC

Osteogenic Composite Matrix, Method for the Production Thereof and Implant and Scaffold for Tissue Engineering Provided with a Coating Formed by Said Osteogenic Composite matrix

InactiveUS20070237799A1Promotes and accelerates accumulationPromotes and accelerates bone and bone growthPowder deliveryPeptide/protein ingredientsFiberCell-Extracellular Matrix
The invention relates to an osteogenic composite matrix consisting of collagen and non-collagen components of an extracellular matrix (ECM-components), to a method for producing said matrix, to a method for producing an implant or a scaffold for tissue engineering which is provided with a coating formed by said osteogenic composite matrix and is used for stimulating and accelerating a hard tissue formation such as, for example the implant osseointegration in bones. The inventive osteogenic composite matrix comprises a collagen and at least one non-collagen ECM component or the derivatives thereof, wherein the collagen component consists of non-crosslinked collagen fibres produced by fibrillogenesis and the non-collagen ECM component or the derivatives thereof are integrated into said collagen fibres.
Owner:NEXILIS

Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from Uncaria tomentosa and related plants

Assay-guided affinity fractionation and reverse phase high pressure liquid chromatography (HPLC) methodology to isolate, test and characterize the most active water-soluble ingredients within Cat's Claw, or Uncaria tomentos. These components appear to account for the majority of the amyloid or Aβ fibrillogenesis inhibitory activity. Individual fractions and / or compounds as isolated by HPLC are tested in relevant in vitro and / or animal models, and found to consistently demonstrate inhibition of amyloid or Aβ fibrillogenesis. Related extraction methods are disclosed.
Owner:COGNITIVE CLARITY INC

Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from Uncaria tomentosa and related plants

Assay-guided affinity fractionation and reverse phase high pressure liquid chromatography (HPLC) methodology to isolate, test and characterize the most active water-soluble ingredients within Cat's Claw, or Uncaria tomentos. These components appear to account for the majority of the amyloid or Aβ fibrillogenesis inhibitory activity. Individual fractions and / or compounds as isolated by HPLC are tested in relevant in vitro and / or animal models, and found to consistently demonstrate inhibition of amyloid or Aβ fibrillogenesis. Related extraction methods are disclosed.
Owner:COGNITIVE CLARITY INC

Methods for drug screen using zebrafish model and the compounds screened therefrom

InactiveUS20140073611A1Reduce rateAffect expressionBiocideSenses disorderDiseaseMedicine
The disclosure relates to a platform of using zebrafish in screening candidates for treating and / or preventing myopia and keratoconus disease. The disclosure is mainly based on that Lumican, one of several SLRPs, plays an important role in the regulation of fibrillogenesis or the genes affecting the size of eyeballs in zebrafish, in addition to playing an important role in clinical myopia. Therefore, the disclosure uses the established zebrafish model to further identify the drugs affecting the expression of lumican and collagen fibrillogenesis, and / or the regulation of eyeball size. These drugs are potential candidates for treating myopia and / or keratoconus disease.
Owner:NAT TAIWAN UNIV

Variant Beta2-microglobulin, characterization of the same and applications thereof

This invention relates to the specific Asp76Asn (D76N) variant β2-microglobulin (β2M) protein, nucleic acids encoding the same, their characterization and applications in studying amyloid fibrillogenesis, including diagnostic and therapeutic applications.
Owner:UCL BUSINESS PLC +2

Amyloid ß fibrillogenesis-inhibiting peptide

The present invention provides a peptide which functions as a mimic peptide of an amyloid β peptide and is capable of inhibiting the fibrillogenesis of an amyloid β peptide. The present invention relates to: an 8- to 30-amino acid residue peptide comprising an amino acid sequence represented by the following formula (I):X1-Asp-X2-X3-X4-Pro-X5-X6  (I)wherein X1 represents a branched chain amino acid, and X2, X3, X4, X5, and X6 are the same or different and each represents an α-amino acid; a 9- to 30-amino acid residue peptide comprising an amino acid sequence represented by the following formula (III):Z1-X13-Gly-X14-X15-Pro-Trp-Met-Z2  (III)wherein X13, X14, and X15 are the same or different and each represents an α-amino acid, Z1 and Z2 are the same or different and each represents cysteine or serine, and when Z1 and Z2 represent cysteine, they may be crosslinked; and a pharmaceutical composition and an amyloid β fibrillogenesis inhibitor comprising the peptide.
Owner:KAGOSHIMA UNIV

Amyloid Beta fibril-decomposing agent, therapeutic/prophylactic agent for disease associated with amyloid Beta fibrillogenesis, and food composition for treating/preventing disease associated with amyloid Beta fibrillogenesis

The purpose of the present invention is to provide: an amyloid Beta fibril-decomposing agent which contains a naturally occurring substance as an active ingredient; a therapeutic or prophylactic agent for a disease associated with amyloid Beta fibrillogenesis; and a food composition for treating or preventing a disease associated with amyloid Beta fibrillogenesis. An amyloid Beta fibril-decomposing agent which contains, as an active ingredient, a dried powder, a milled product and / or an extract of an earthworm; a therapeutic or prophylactic agent for a disease associated with amyloid Beta fibrillogenesis; and a food composition for treating or preventing a disease associated with amyloid Beta fibrillogenesis. The disease associated with amyloid Beta fibrillogenesis is preferably Alzheimer's disease.
Owner:WELL STONE

Proanthocyanidins for the Treatment of Amyloid and Alpha-Synuclein Diseases

InactiveUS20100010079A1Detailed characterizationPotent activityBiocideNervous disorderProanthocyanidinAmyloid disease
A method of treating an amyloid disease, or a disease characterized by α-synuclein or NAC fibrillogenesis, in a mammalian subject. The method includes administering to the mammal a therapeutically effective amount of a various disclosed proanthocyanidins or a proanthocyanidin characterized by disclosed general formulae. A pharmaceutical composition comprising a therapeutically effective amount of a proanthocyanidin and a pharmaceutically acceptable excipient. The therapeutic amount of the proanthocyanidin is selected for efficacy in treating amyloid, α-synuclein or NAC fibrillogenesis in a mammalian subject.
Owner:COGNITIVE CLARITY INC

Method and Composition for Treating a Fibrotic Disorder

α2-macroglobulin-related agents for treating or preventing a fibrotic disorder associated with fibrillogenesis are disclosed along with methods for using the agents, as well as methods for producing agents suited for use in the disclosed methods for treating or preventing a fibrotic disorder.
Owner:WISCONSIN ALUMNI RES FOUND

Switch-Peptides as Tool for the Study of Fibrillogenesis

The present invention relates to a method for the manufacture of a peptidic folding precursor (Switch-Peptide) stable and soluble at physiological conditions, derived from a peptide having a potential for self-assembling and fibrillogenesis. Another object of the invention is to provide a tool for the quantitative, controlled in vitro study of fibrillogenesis and its inhibition of peptides involved in degenerative diseases.
Owner:ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)

Amyloid [β] Beta fibrillogenesis-inhibiting peptide

The present invention provides a peptide which functions as a mimic peptide of an amyloid β peptide and is capable of inhibiting the fibrillogenesis of an amyloid β peptide. The present invention relates to: an 8- to 30-amino acid residue peptide comprising an amino acid sequence represented by the following formula (I):X1-Asp-X2-X3-X4-Pro-X5-X6 (SEQ ID NO: 28)  (I)wherein X1 represents a branched chain amino acid, and X2, X3, X4, X5, and X6 are the same or different and each represents an α-amino acid; a 9- to 30-amino acid residue peptide comprising an amino acid sequence represented by the following formula (III):Z1-X13-Gly-X14-X15-Pro-Trp-Met-Z2 (SEQ ID NO: 31)  (III)wherein X13, X14, and X15 are the same or different and each represents an α-amino acid, Z1 and Z2 are the same or different and each represents cysteine or serine, and when Z1 and Z2 represent cysteine, they may be crosslinked; and a pharmaceutical composition and an amyloid β fibrillogenesis inhibitor comprising the peptide.
Owner:KAGOSHIMA UNIV
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