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Preparation method and application of blumea balsamifera effective component

An effective component, the technology of Ainaxiang, which is applied in the field of preparation of the effective components of Ainaxiang, can solve the problems of the material basis of medicinal effect and the unclear effective components of medicine, and achieve low toxicity, wide sources and remarkable effect Effect

Inactive Publication Date: 2017-12-15
GUIZHOU MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Studies have shown that Ainaxiang has obvious anti-inflammatory effects and can be used to treat rheumatoid arthritis, but its medicinal material basis and medicinal active components are still unclear

Method used

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  • Preparation method and application of blumea balsamifera effective component
  • Preparation method and application of blumea balsamifera effective component
  • Preparation method and application of blumea balsamifera effective component

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Component preparation

[0022] Take 160g of Ainaxiang medicinal material section (3~5cm long), extract 2 times with 12 times the amount (1920mL) of 25% ethanol aqueous solution, 2 hours / time, filter, combine the filtrates and concentrate to extract (Ainaxiang medicinal material total extract) 36.8g, add 2 times (75mL) water to mix and dissolve, then extract with 2 times the volume of ethyl acetate and n-butanol, and concentrate each extract respectively to obtain 4.4g of ethyl acetate extract, n-butanol Alcoholic extract 4.8g, water part 26.2g. The specific preparation process is as figure 2 shown.

[0023] (2) Characterization of effective components

[0024] Get the n-butanol extract prepared in (1), after dissolving with 50% methanol, adopt high performance liquid chromatography [chromatographic conditions: Agilent Eclipse Plus C18 column (1.8 μm, 150mm × 2.1mm), mobile phase is 0.1 % formic acid water (A)-0.1% formic acid acetonitrile (B), the flow rate is ...

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Abstract

The invention discloses a preparation method and application of a blumea balsamifera effective component. A preparation process comprises the following steps: taking blumea balsamifera and extracting the blumea balsamifera with an ethanol water solution to obtain an extracting solution; concentrating the extracting solution until the extracting solution has no alcohol taste; adding water for diluting and extracting by utilizing ethyl acetate and n-butyl alcohol respectively to obtain ethyl acetate extract and n-butyl alcohol extract; drying a water part and an n-butyl alcohol extracting part to obtain the effective component. The preparation method and the application of the blumea balsamifera effective component have the beneficial effects that a xylol caused mouse ear swelling test and a mouse abdominal cavity capillary permeability increasing test determine that the obtained effective component has good anti-inflammatory activity.

Description

technical field [0001] The invention belongs to the technical field of preparation method and application of effective components of traditional Chinese medicinal materials, and in particular relates to a preparation method and application of effective components of Ainaxiang. Background technique [0002] Inflammation is the defense response of living tissue with vascular system to damage factors, manifested as redness, swelling, heat, pain and dysfunction. Inflammation is a unified process of injury and anti-injury. On the one hand, injury factors directly or indirectly cause tissue and cell destruction; Repair and heal damaged tissues. However, excessive inflammation or prolonged inflammatory process can cause inflammatory disorders and dysfunction of related organs, including diabetes, meningitis, and rheumatism. In recent years, the treatment of inflammatory diseases has become one of the main goals of the global pharmaceutical industry. At present, many drugs includi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P29/00
CPCA61K36/28A61K2236/333A61K2236/51A61K2236/55
Inventor 李勇军张宝彭潇孙绪巩仔鹏马雪孙佳黄勇刘亭兰燕宇
Owner GUIZHOU MEDICAL UNIV
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