Application of ulinastatin containing composition in preparation of drugs for treating skin damage caused by radiotherapy and chemotherapy

A skin injury and ulinastatin technology, applied in the field of medicine, can solve problems such as restricted application, no puerarin skin injury, and intravascular hemolysis, so as to improve safety, inhibit hair follicle cell apoptosis, and promote hair growth. The effect of regeneration

Active Publication Date: 2017-12-26
GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, no research on puerarin in the treatment of skin damage caused by radiotherapy and chemotherapy has been found, and because puerarin injection is easy to cause intravascular hemolysis, its application is greatly restricted

Method used

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  • Application of ulinastatin containing composition in preparation of drugs for treating skin damage caused by radiotherapy and chemotherapy
  • Application of ulinastatin containing composition in preparation of drugs for treating skin damage caused by radiotherapy and chemotherapy
  • Application of ulinastatin containing composition in preparation of drugs for treating skin damage caused by radiotherapy and chemotherapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Ulinastatin and Puerarin Compound Injection

[0023] Ulinastatin

[0024] Preparation process: take prescribed amount of ulinastatin and puerarin, dissolve in 500ml 5% glucose injection, filter, pot, and sterilize to obtain.

Embodiment 2

[0025] Example 2 Ulinastatin and Puerarin Compound Injection

[0026] Ulinastatin

[0027] Preparation process: take prescribed amount of ulinastatin and puerarin, dissolve in 500ml 5% glucose injection, filter, pot, and sterilize to obtain.

Embodiment 3

[0028] Example 3 Ulinastatin and Puerarin Compound Injection

[0029] Ulinastatin

[0030] Preparation process: take prescription amount of ulinastatin and puerarin, dissolve in 500ml 0.9% sodium chloride injection, filter, pot, and sterilize.

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PUM

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Abstract

The invention relates to an application of an ulinastatin containing composition in the preparation of drugs for treating skin damage caused by radiotherapy and chemotherapy. The composition is composed of ulinastatin and puerarin according to a mass ratio of 1:0.1-1, preferably 1:0.45. The composition can well prevent and treat skin damage caused by radiotherapy and chemotherapy, in particular, hair follicle tissue damage caused by radiotherapy, phlebitis and extravasation injury caused by chemotherapy, and dermatitis caused by radiotherapy. The dosage of ulinastatin is reduced, and a good effect is achieved at the same time. Moreover, hemolysis caused by puerarin is inhibited effectively.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically discloses the use of a composition containing ulinastatin in the preparation of medicines for treating skin damage caused by radiotherapy and chemotherapy. Background technique [0002] Radiation therapy (radiotherapy) and chemotherapeutics (chemotherapy) are currently one of the important means of treating malignant tumors, but both radiotherapy and chemotherapy will cause systemic and local toxic reactions, seriously affecting the quality of life of patients, and bringing serious harm to patients. Great pain. Among them, hair loss is a common adverse reaction of radiotherapy and chemotherapy. Although the molecular mechanism of hair loss caused by radiotherapy and chemotherapy is not very clear, it is generally believed that radiotherapy and chemotherapy can cause apoptosis of hair follicle cells in the skin, resulting in hair loss. [0003] In addition, during the infusion ...

Claims

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Application Information

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IPC IPC(8): A61K38/57A61P17/00A61P17/02A61P9/14A61K31/352
CPCA61K31/352A61K38/57A61K2300/00
Inventor 宋建东余秋琼蔡榕香刘飞
Owner GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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