Kit for detecting versican V1 mRNA in urine and its application

A detection kit and detection reagent technology, applied in the field of medical detection, can solve the problems of poor long-term prognosis and severe clinical pathological damage, and achieve the effects of rapid and accurate detection of detection methods and convenient clinical application.
CN107858417BActive Publication Date: 2020-06-05NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A
Publication Date
2020-06-05

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Abstract

The invention belongs to the field of medical science detection, and especially relates to a kit for detecting versican V1mRNA in urine, and an application thereof. The urine of a patient is collected, and the versican V1mRNA level of urinary sediment is determined. A result shows that the versican V1mRNA level of the urinary sediment of an FSGS patient is significantly increased, and the versicanV1mRNA level of the urinary sediment of a minimal change disease (MCD) patient has no change; and the versican V1mRNA level of the urinary sediment of the FSGS patient is associated with the tubulointerstitial fibrosis score of the patient, and is significantly associated with the decline rate of eGFR during patient follow-up, so the expression level of the versican V1mRNA in urine can be used for the prognostic diagnosis of the FSGS patient. A reagent for detecting the versican V1mRNA expression level of urine can be used to prepare a detection reagent or the detection kit in order to realize the non-invasive diagnosis of the FSGS prognosis.
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Description

technical field

[0001] The invention belongs to the field of medical detection, in particular to a kit for detecting versican V1 mRNA in urine and its application in the prognosis diagnosis of focal segmental glomerulosclerosis. Background technique

[0002] Focal Segmental Glomerular Sclerosis (FSGS) is a typical podocyte disease. Most of the patients have non-selective proteinuria, and hypertension and renal dysfunction are more common at the onset, often accompanied by renal tubular dysfunction. Pathologically, focal segmental lesions of glomeruli and acute and chronic lesions of tubulointerstitium can be seen in patients with FSGS. Although FSGS and minimal change disease (MCD) belong to the same podocyte disease, the clinicopathological damage is more severe than that of MCD, and the long-term prognosis is worse than that of MCD. The degree of chronic tubulointerstitial disease is closely related to the prognosis of FSGS. It is of great practical significance to find...

Claims

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