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Application of chloroquine to promote spinal cord damage repair

A spinal cord injury and chloroquine technology, applied in the field of pharmaceutical compositions, can solve the problems of undiscussed spinal cord injury and unresearched inflammation

Active Publication Date: 2018-04-03
慈溪市人民医院医疗健康集团
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, the regulatory role of autophagy on inflammation mediated by ubiquitinated proteins has not been deeply studied in the past, especially the significance in the repair and reconstruction of spinal cord injury has not been explored

Method used

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  • Application of chloroquine to promote spinal cord damage repair
  • Application of chloroquine to promote spinal cord damage repair
  • Application of chloroquine to promote spinal cord damage repair

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Embodiment Construction

[0020] The following description serves to disclose the invention to enable those skilled in the art to practice the invention. The preferred embodiments described below are given by way of example only, and other obvious modifications will occur to those skilled in the art. The basic principles of the invention defined in the following description may be applied to other embodiments, variations, improvements, equivalents, and other technical solutions without departing from the spirit and scope of the invention.

[0021] Chloroquine and / or its composition according to the present invention refers to containing according to conventional chloroquine (Chloroquine, CQ) and / or its pharmaceutically acceptable carrier, adjuvant or vehicle, its specific usage amount and In addition to the methods provided according to the present invention, the usage method also includes usages in accordance with other medicines.

[0022] According to an embodiment of the present invention, firstly,...

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Abstract

The invention provides an application of chloroquine to promote spinal cord damage repair. Chloroquine can inhibit degradation of ubiquitinated protein I-kB[alpha], so that autophagy regulating inflammation can be inhibited to promote spinal cord damage repair. Degradation of ubiquitinated protein I-kB[alpha] can be regulated according to a reaction mechanism of p62-mediated autophagy regulating inflammation LC3-II-p62-I-kB[alpha]. Chloroquine is further introduced to intervene in degradation of ubiquitinated protein I-kB[alpha].

Description

technical field [0001] The invention relates to the field of pharmaceutical compositions, in particular to the application of chloroquine to promote spinal cord injury repair and inhibit inflammatory response by regulating autophagy and inflammatory response. Background technique [0002] Spinal cord injury (SCI) is a serious neurological trauma. With the sharp increase in the incidence of spinal cord injury, it has brought a heavy burden to patients and the whole society. What is frustrating is that despite the efforts of neuroscience researchers around the world for more than a hundred years, the therapeutic effect of spinal cord injury is still unsatisfactory. The factors are diverse and the environment is complex. The current research believes that spinal cord injury includes two mechanisms, namely primary injury and secondary injury. The primary injury is the injury caused by external force or fracture and dislocation at the moment of injury, which is irreversible. S...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D215/46A61P25/00G01N33/68
CPCC07D215/46G01N33/6893
Inventor 邬芬赞肖健张宏宇魏晓捷童松林
Owner 慈溪市人民医院医疗健康集团
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