Novel gentiana capsule optimized medicinal composition as well as application thereof in analgesia, anti-inflammatory and cholagogic aspects

A technology of composition and medicine, applied in the optimized pharmaceutical composition of the new Geranium Capsules and its application in analgesia, choleretic and anti-inflammation

Active Publication Date: 2018-05-18
XIAN C P PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no research report on the content of active ingredients and related HPLC fingerprints of Jialong Capsules

Method used

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  • Novel gentiana capsule optimized medicinal composition as well as application thereof in analgesia, anti-inflammatory and cholagogic aspects
  • Novel gentiana capsule optimized medicinal composition as well as application thereof in analgesia, anti-inflammatory and cholagogic aspects
  • Novel gentiana capsule optimized medicinal composition as well as application thereof in analgesia, anti-inflammatory and cholagogic aspects

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The establishment of embodiment 1 fingerprint

[0023] 1 Instruments and reagents

[0024] Shimadzu high performance liquid chromatography (LC-2010C HT , LC / Labsoluion chromatographic workstation), Japan Shimadzu Corporation; German sartorius electronic balance, model CPA225D, Germany Sartorius Company; ultrasonic generator, model KQ-5200DE numerical control, Kunshan Ultrasonic Instrument Co., Ltd. Acetonitrile, methanol, chromatographic grade, U.S. Honeywell Company; Ultrapure water, is made by U.S. Millipore pure water instrument, U.S. Millipore Company; 111873-201103, the content is 98.3%), swerticin (batch number 110785-201404, the content is 98.3%), gentiopicroside (batch number 110770-201716, the content is 99.1%), isoorientin (batch number 111974 -201401, with a content of 94.0%) and other reference substances were purchased from China National Institute for the Control of Pharmaceutical and Biological Products; Reference substances such as glucoside (batch nu...

Embodiment 2

[0034] The content determination of each component of embodiment 2 Geranium Capsules

[0035] 3.1 Chromatographic conditions The recording time is 60 minutes, and the rest are the same as 2.1 in Example 1.

[0036] 3.2 Preparation of reference substance solution Accurately weigh a certain amount of shanzhiside methyl ester, swerticroside, swertigin, isoorientin, isovitexin, loganinic acid, 6′-O -β-D-glucosyl gentiopicroside, gentiopicroside, configured as a reference substance mixed solution, loganinic acid, shanzhiside methyl ester, 6′-O-β-D- The concentrations of glucosylgentiopicroside, swertiamarin, gentiopicroside, swertiin, isoorientin, and isovitetin reference substances were 2100.00, 320.00, 1500.00, 510.00, 3900.00, 420.00, 220.00, 110μg·mL -1 .

[0037] 3.3 The preparation of the test solution is the same as 2.2.2 in Example 1.

[0038] 3.4 Linear relationship Precisely measure 0.01, 0.05, 0.10, 0.25, 0.50 and 1.00mL of the reference substance mixture prepared in...

Embodiment 3

[0055] Raw materials: 120 parts of loganinic acid, 10 parts of shanzhiin methyl ester, 40 parts of 6′-O-β-D-glucosyl gentiopicroside, 10 parts of swertiamarin, 500 parts of gentiopicroside , 8 parts of swertigin, 1 part of isoorientin, and 1 part of isovitexin.

[0056] According to the above parts by weight, loganinic acid 120mg, shanzhiin methyl ester 10mg, 6'-O-β-D-glucosylgentiopicroside 40mg, swerbroside 10mg, gentiopicroside 500mg, Tablets can be prepared from 8 mg of glucoside, 1 mg of isoorientin, and 1 mg of isovitexin.

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Abstract

The invention belongs to and relates to a novel gentiana capsule optimized medicinal composition as well as application thereof in analgesia, anti-inflammatory and cholagogic aspects. The invention provides a gentiana capsule optimized medicinal composition; the gentiana capsule optimized medicinal composition is prepared from the following effective components: 120 to 150 parts of loganic acid, 5to 10 parts of shanzhiside methyl ester, 40 to 45 parts of 6'-O-beta-D-glucosyl gentiopicrin, 10 to 15 parts of swertiamarine, 500 to 520 parts of gentiopicrin, 8 to 10 parts of sweroside, 1 to 2 parts of isoorientin and 1 to 2 parts of isovitexin. The medicinal composition has the advantages that the activity of the medicinal composition in the analgesia, anti-inflammatory and cholagogic aspectsis obviously superior to that of the gentiopicrin, the gentiana capsule and gentian total glycoside extract at the aboveground part of the gentian.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compositions, and in particular relates to a novel optimized pharmaceutical composition of Geranium Capsules and its application in the aspects of analgesia, anti-inflammation and choleretic. Background technique [0002] The main ingredient of Gentiana Capsules is the extract of Gentiana chinensis, a natural plant medicinal material. It is mainly used to clear the liver and expel heat. It is used for functional dyspepsia with liver and stomach stagnation heat syndrome. Gentiana macrophylla is a plant of Gentianaceae (Gentianaceae). Its root is one of the important traditional Chinese medicinal materials in my country. It was first recorded in "Shen Nong's Materia Medica". pee. Predecessors have done a lot of research on the chemical components of Gentiana officinalis in Shaanxi. The main components of Gentiana officinalis are secoiridoid glycosides, of which gentiopicroside has the highest content. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/352A61P29/00A61P1/16
CPCA61K31/352A61K31/7048A61K2300/00
Inventor 高茂煌刘铁明袁鹰董明芝许志红
Owner XIAN C P PHARMA
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