Medicament to treat vascular dementia

A vascular dementia and drug technology, applied in drug combinations, cardiovascular system diseases, pharmaceutical formulations, etc., to achieve the effects of treating cognitive symptoms, improving mental retardation, and improving clinical efficacy

Active Publication Date: 2018-06-12
SHENZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the inventors have found in clinical practice that the above-me

Method used

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  • Medicament to treat vascular dementia
  • Medicament to treat vascular dementia
  • Medicament to treat vascular dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Embodiment 1 (granule)

[0068] 1. Prescription:

[0069] Astragalus 346g, Chuanxiong 316.5g, Gastrodia elata 237g, Angelica 158g, Sangji 127g, Ligustrum lucidum 127g, Eclipta 119.5g, Chinese yam 79g, licorice 40g.

[0070] 2. Preparation method:

[0071] (1) Get 118.5g of Gastrodia elata consumption and dry and pulverize into Gastrodia elata fine powder;

[0072] (2) Take the remaining Gastrodia elata and the remaining 8 flavors, add water to decoct twice, add water 8 times for 2 hours each time;

[0073] (3) Combine the decoctions, filter, concentrate to a thick paste with a relative density of 1.30 at 80°C, let it cool, add 2 times the amount of ethanol, stir evenly, let stand for 24 hours, take the supernatant, recover the ethanol, and concentrate to Thick paste with a relative density of 1.30 at 80°C;

[0074] (4) Mix the thick ointment with Gastrodia elata fine powder, dry at 70°C, and pulverize into fine powder;

[0075] (5) Add water to make granules, dry a...

Embodiment 2

[0076] Embodiment 2 (granule)

[0077] 1. Prescription:

[0078] Astragalus 407.4g, Chuanxiong 338.3g, Gastrodia elata 230.6g, Angelica 138.4g, Sangji 100.8g, Ligustrum lucidum 111.5g, Eclipta 103.8g, Chinese yam 76.9g, licorice 42.3g.

[0079] 2. Preparation method:

[0080] (1) Get 115.3g of Gastrodia elata consumption and dry and pulverize into Gastrodia elata fine powder;

[0081] (2) Take the remaining Gastrodia elata and the remaining 8 flavors, add water to decoct twice, add water 6 times for 2 hours each time;

[0082] (3) Combine the decoctions, filter, concentrate to a thick paste with a relative density of 1.30 at 80°C, let it cool, add 2 times the amount of ethanol, stir evenly, let stand for 24 hours, take the supernatant, recover the ethanol, and concentrate to Thick paste with a relative density of 1.30 at 80°C;

[0083] (4) Mix the thick ointment with Gastrodia elata fine powder, dry at 65°C, and pulverize into fine powder;

[0084] (5) Add water to make g...

Embodiment 3

[0085] Embodiment 3 (granule)

[0086] 1. Prescription:

[0087] Astragalus 306.1g, Chuanxiong 371.9g, Gastrodia elata 209.3g, Angelica 139.5g, Sangji 124.0g, Ligustrum lucidum 135.6g, Eclipta 139.5g, Chinese yam 85.3g, licorice 38.8g.

[0088] 2. Preparation method:

[0089] (1) Get 104.6g of Gastrodia elata consumption and dry and pulverize into Gastrodia elata fine powder;

[0090] (2) Take the remaining Gastrodia elata and the remaining 8 flavors, add water to decoct twice, add water 10 times for 2 hours each time;

[0091] (3) Combine the decoctions, filter, concentrate to a thick paste with a relative density of 1.30 at 80°C, let it cool, add 2 times the amount of ethanol, stir evenly, let stand for 24 hours, take the supernatant, recover the ethanol, and concentrate to Thick paste with a relative density of 1.30 at 80°C;

[0092] (4) Mix the thick ointment with Gastrodia elata fine powder, dry at 75°C, and pulverize into fine powder;

[0093] (5) Add water to make ...

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PUM

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Abstract

The invention relates to a medicament to treat vascular dementia, composed of an effective ingredient and a pharmaceutically acceptable excipient, wherein the effective ingredient is made from, by weight, 17.5-26.5% of root of Mongolian milkvetch, 16-24% of chuanxiong rhizome, 12-18% of rhizome of tall gastrodia, 8-12% of root of Chinese angelica, 6.5-9.5% of Chinese taxillus herb, 6.5-9.5% of fruit of glossy privet, 6-9% of yerbadetajo herb, 4-6% of rhizome of common yam, and 2-3% of root of ural licorice. Clinical verification shows that the medicament can treat both symptoms and root causes, can regulate both deficiency and excess and can significantly effectively treat vascular dementia.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition prepared from raw materials of Chinese medicinal materials. Background technique [0002] Dementia is a clinical syndrome that describes a series of abnormalities in learning and memory, behavior and reasoning, complex attention, and executive function caused by dysfunction or death of neurons in the brain. Vascular dementia is one of the common types of dementia. The main clinical symptoms are abnormal gait, frequent urination, urgency, memory loss, forgetfulness, and decreased thinking and learning ability. With the aging of the social population and the increasing incidence of cardiovascular and cerebrovascular diseases, the incidence of VD is increasing rapidly. Dementia epidemiology predicts that the number of dementia patients will double every 20 years. According to this, there will be 66 million dementia patients in ...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61P25/28A61P9/10
CPCA61K36/185A61K36/232A61K36/236A61K36/28A61K36/481A61K36/484A61K36/638A61K36/8945A61K36/8988A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 虢周科
Owner SHENZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL
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