Traditional Chinese medicine composition of Gengchen preparation, preparation method, detection method and application thereof

A composition and preparation technology, applied in the field of traditional Chinese medicine, can solve problems such as unguaranteed product quality, reduction of active ingredients, and unqualified product quality, and achieve the effects of improving autonomous activities, symptoms, and depression

Active Publication Date: 2018-12-21
HEFEI YIFAN PHARMA MANAGEMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Depression is now beginning to be younger and younger, and the existing gengchen preparations contain velvet and musk, and their raw materials are obtained from rare animals, with limited output and high cost. They are urgently needed and low in cost. Alternative products used by younger people
[0006] In addition, because there are many products of Gengchen preparations, during its preparation, the extracted extract may be shoddy, resulting in a reduction in the amount of its main active ingredients, causing the quality of the product to be unqualified, and the quality of the product cannot be guaranteed. A method for effectively detecting and identifying gengchen preparations

Method used

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  • Traditional Chinese medicine composition of Gengchen preparation, preparation method, detection method and application thereof
  • Traditional Chinese medicine composition of Gengchen preparation, preparation method, detection method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A kind of preparation of Gengchen preparation, it comprises the steps:

[0042] S1. Preparation of ginseng extract: take ginseng and add 4 to 6 times the weight of 65% to 75% ethanol solution, heat and reflux for extraction for 3 to 4 hours, filter out the dregs, recover the ethanol extract, and concentrate the ethanol extract (rotary Evaporate and concentrate, the temperature is 60-70 ℃) until the water is 15%-30% of the clear paste for later use, take the above-mentioned dregs and decoct twice with 3-5 times the weight of water, decoct for the first time for 3 hours, filter and take Decoct the dregs for the second time, add 3 to 5 times the weight of the dregs in water, decoct for 2 hours, filter the decoction, combine the two filtrates, add the above clear paste, and continue to concentrate until the water is 15% ~20%, get ginseng extract;

[0043] S2: Preparation of Cistanche Herba Extract: Take Cistanche Herba Extract and crush it into coarse powder, add 6 to 10 t...

Embodiment 2

[0047] Example 2 Effects of Gengchen Preparation on the Behavior of Depression Rats with Kidney-Yang Deficiency

[0048] The Gengchen preparation prepared on the basis of Example 1, and carry out following experiments:

[0049] Prescription: 20g ginseng extract, 20g epimedium extract, 20g cistanche extract, 10g oryzanol, 5g panax notoginseng powder, vitamin B 1 5g, vitamin E 20g, mixed extract 8g.

[0050] Preparation method: S1: Preparation of ginseng extract: take ginseng and add 5 times the weight of 70% ethanol solution, heat and reflux for extraction for 4 hours, filter out the medicinal residues, recover ethanol, concentrate until the water is 25% clear ointment for later use, take the above medicinal residues Decoct twice with 4 times the weight of water, decoct for 3 hours for the first time, decoct for 2 hours for the second time, filter the decoction, combine the filtrates, add the above clear paste, continue to concentrate until the water is 18%, and obtain ginseng...

Embodiment 3

[0083] Example 3 Simultaneous determination of the contents of echinacoside, verbascoside and icariin in Gengchen preparations by HPLC

[0084] According to literature research, the main components in Epimedium are icariin, etc., and the main chemical components in Cistanche are echinacoside and verbascoside, so for Gengchen preparations containing Epimedium extract and Cistanche extract , In terms of index component control, three components echinacoside, verbascoside and icariin can be selected for quality control. This experiment is an HPLC method for simultaneous determination of the contents of these three components in Gengchen preparation.

[0085] 1 Instruments and reagents

[0086] 1.1 Instruments Agilent 1200 high performance liquid chromatography; electronic balance, Mettler-Toledo.

[0087] 1.2 Reference substances Echinacoside reference substances, verbascoside reference substances, and icariin reference substances were all purchased from Shenzhen Faith Biotechno...

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Abstract

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition of Gengchen preparation, a preparation method, a detection method and application thereof. The traditional Chinese medicine composition of Gengchen preparation comprises the following raw materials in parts by weight: 17-23 parts of radix ginseng extract, 17-23 parts of epimedium herb extract, 17-23 parts of herba cistanches extract, 8-12 parts of oryzanol, 10-15 parts of radix notoginseng powder, 4-6 parts of vitamin B1, 17-23 parts of vitamin E, and 7-10 parts of mixed extract. A new pharmaceutical use of Gengchen preparation for treating depression caused by kidney yang deficiency and menopausal syndrome is provided, and a high performance liquid chromatographymethod for simultaneously determining the contents of several main active ingredients in the Gengchen preparation is also provided.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition, preparation method, detection method and application of Gengchen preparation. Background technique [0002] Menopausal syndrome refers to the reduction of estrogen secretion caused by ovarian failure caused by physiology or pathology or surgery, which in turn leads to the degenerative changes of a large number of organs and tissues controlled and dominated by estrogen in women's bodies. A group of syndromes mainly characterized by dysfunction of the autonomic nervous system, accompanied by mental and psychological symptoms. The disease is caused by the disorder of hormone level, which will have a significant impact on the physiology and psychology of menopausal women, showing a sub-health state of reduced living ability, reduced social adaptability and physical discomfort. When it is severe, it can lead to depression. It is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P15/12A61P25/24G01N30/02G01N30/06G01N30/14G01N30/54A61K31/355A61K31/51A61K31/575
CPCA61K36/888A61K36/9066A61P15/12A61P25/24G01N30/02G01N30/06G01N30/14G01N30/54A61K31/355A61K31/51A61K31/575A61K36/232A61K36/258A61K36/296A61K36/64A61K36/815A61K2236/39A61K2236/333A61K2236/331G01N2030/062G01N2030/027A61K2300/00
Inventor 何枢衡吴建雄周文艳刘存鲍春影
Owner HEFEI YIFAN PHARMA MANAGEMENT
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