Effects of batroxobin in promoting survival of ischemic super-long random flap

A technology of batroxobin and pure batroxobin, applied in the field of the role of batroxobin in promoting the survival of ischemic ultra-long random skin flaps

Inactive Publication Date: 2018-06-15
THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no research report on the effect of batroxobin on random skin flaps at home and abroad

Method used

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  • Effects of batroxobin in promoting survival of ischemic super-long random flap
  • Effects of batroxobin in promoting survival of ischemic super-long random flap
  • Effects of batroxobin in promoting survival of ischemic super-long random flap

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] Batroxobin can significantly improve the survival of ischemic ultra-long random flaps. In the process of promoting the survival of ischemic ultra-long random skin flaps, intravenous injection was used. 1ml of pure batroxobin powder containing batroxobin 10BU was dissolved in 49ml of normal saline to prepare 0.2 The batroxobin injection solution of BU / ml is injected according to 5BU / Kg, that is, the dose of pure batroxobin injected with 5BU per kilogram of body weight (Brabender Units (BU) is a proprietary unit, referring to Brabender Viscometer Viscosity unit obtained), the method of use is once a day, and the dosage is to inject 5BU of pure batroxobin per kilogram, using tail vein injection, 5 to 7 days as a course of treatment. The following is the evaluation of the role of batroxobin in promoting the survival of ischemic ultra-long random flaps:

[0019] 1. Establish random flap model of SD rats

[0020] Thirty clean-grade male SD rats were provided by the Experime...

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Abstract

The invention relates to effects of batroxobin in promoting the survival of ischemic super-long random flap. A tail vein injection mode is used in the process of promoting the survival of the ischemicsuper-long random flap; a use method is that tail vein injection of 5BU / kg pure batroxobin is performed every day, with 5 to 7 days as one treatment course. A conclusion can be drawn through a largenumber of animal experiments; the survival area ratio of the flap can be greatly improved by using the batroxobin, so that the survival of the ischemic super-long random flap can be well promoted.

Description

technical field [0001] The invention relates to a new application of batroxobin, in particular to the role of batroxobin in promoting the survival of ischemic ultra-long random skin flaps. Background technique [0002] In recent years, with the advancement of science and technology, industry, transportation, energy, etc. have shown rapid development, and the pace of people's work and life has been greatly accelerated, resulting in an increase in cases of large-scale trauma and tissue defects related to occupations, traffic behaviors, etc. reduce. This type of trauma usually leaves different degrees of deformity and dysfunction after repair, especially trauma deformity of the hands and face. In addition, in the field of microscopic reconstruction of the hand, plastic surgery, trauma orthopedics and other fields, flap transfer surgery is often required to lock the wound, reconstruct function and improve appearance. Plastic surgery has been competing between "beauty" and "blo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/48A61P9/10
Inventor 林丁盛方妙杰齐朝阳闫合德高伟阳
Owner THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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