Effect of paeoniflorin in preparation of medicine for promoting survival of ischemic super-long random skin flap

A technology of paeoniflorin and medicine, which is applied in the field of action of medicine to achieve the effects of inhibiting cell pyroptosis, increasing the survival area ratio, and reducing inflammatory response

Pending Publication Date: 2022-05-31
THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of paeoniflorin on skin flap survival has not been reported, and the study of its new curative effect has broad economic and social benefits

Method used

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  • Effect of paeoniflorin in preparation of medicine for promoting survival of ischemic super-long random skin flap
  • Effect of paeoniflorin in preparation of medicine for promoting survival of ischemic super-long random skin flap
  • Effect of paeoniflorin in preparation of medicine for promoting survival of ischemic super-long random skin flap

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: the preparation method of paeoniflorin injection

[0021] Its preparation method steps are as follows

[0022] 1g of paeoniflorin powder was dissolved in 100ml of normal saline to make a 10mg / ml solution.

[0023] Wherein the chemical structural formula of paeoniflorin is as follows:

[0024]

Embodiment 2

[0025] Example 2: Establishment of random skin flap model of ischemia

[0026] 60 SD rats, provided by the Experimental Animal Center of Wenzhou Medical University, clean grade, weighing 200-250 g, aged 2-3 months. They were randomly divided into normal saline control group (control group), low-dose paeoniflorin group (Riv-L group) and high-dose group (Riv-H group), 20 rats in each group. Rats were anesthetized by intraperitoneal injection of 1% sodium pentobarbital (40mg / Kg), and the limbs and teeth were fixed in prone position. After the anesthesia took effect, the hair on the back trunk of the rat was preliminarily shaved with a shaver, the unremoved hair was moisturized with distilled water, and the depilatory cream was evenly applied. After waiting 3 minutes, gently remove the cream with a plastic sheet and repeat the process until the hair is completely removed. Design a modified McFarlane flap whose longitudinal axis is parallel to the long axis of the back of the rat...

Embodiment 3

[0028] Example 3: Detection of skin flap survival area ratio and skin flap survival status

[0029] Flap Survival Area Ratio and Flap Survival Condition Detection 1-7 days after operation, the color, texture, tissue elasticity, and hair growth or necrosis of rats were observed with the naked eye. Seven days after operation, the rats were anesthetized with 100 g / L chloral hydrate (8 mL / kg) and sacrificed. The surviving area of ​​the flap and the total flap area of ​​the rat were accurately traced and cut with transparent paper, and the mass was weighed with an electronic scale. Calculate the percentage of flap survival area [flap survival area transparent paper mass ÷ total flap surface area transparent paper mass × 100%]. Each rat was measured twice, and the average value was taken. The surviving area is pink, soft in texture, and has new hair growth; the necrotic area is black in color of the flap, the tissue retracts, has poor elasticity, and is hard in texture, and the cut...

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Abstract

The invention relates to an effect of paeoniflorin in preparation of a medicine for promoting ischemic random skin flap survival, an intravenous injection mode is adopted in the process of promoting ischemic random skin flap survival, a conclusion is drawn through a large number of animal experiments, the survival area ratio of skin flaps can be obviously increased by using paeoniflorin, and the survival rate of the skin flaps can be obviously increased by using paeoniflorin. The survival of ischemic random skin flaps can be well promoted.

Description

technical field [0001] The invention relates to a new application of paeoniflorin, in particular to the role of paeoniflorin in preparing a drug for promoting the survival of ischemic ultra-long random skin flaps. Background technique [0002] In recent years, with the continuous improvement of my country's economic level, industries such as industry and energy have shown a trend of rapid development, and the resulting cases of large-area trauma and tissue defects related to occupations and traffic behaviors are also increasing. This type of trauma usually leaves different degrees of deformity and dysfunction after repair, especially trauma deformity of the hands and face. As patients' requirements for perfect appearance and functional recovery are increasing day by day, the repair technology and treatment methods for wound problems have become an important consideration in medicine. Clinically, as the most basic and most commonly used surgical method for wound repair, rand...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K36/71A61K36/65A61P17/02
CPCA61K31/7048A61K36/71A61K36/65A61P17/02
Inventor 林丁盛李文杰范伟剑
Owner THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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