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Effect of catalpol in preparation of medicine for promoting survival of ischemic super-long random skin flap

A drug, ultra-long technology, applied in the direction of drug delivery, drug combination, pharmaceutical formulation, etc., to achieve the effect of promoting survival and improving the survival area ratio

Pending Publication Date: 2022-05-13
THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of catalpol glycosides on skin flap survival has not been reported, and the study of its new curative effect has broad economic and social benefits

Method used

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  • Effect of catalpol in preparation of medicine for promoting survival of ischemic super-long random skin flap
  • Effect of catalpol in preparation of medicine for promoting survival of ischemic super-long random skin flap
  • Effect of catalpol in preparation of medicine for promoting survival of ischemic super-long random skin flap

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: the preparation method of catalpol injection

[0023] Its preparation method steps are as follows

[0024] 1g of catalpol powder was dissolved in 1000ml of normal saline to make a 1mg / ml solution.

[0025] Wherein the chemical structural formula of catalpol is as follows:

[0026]

Embodiment 2

[0027] Example 2: Establishment of random skin flap model of ischemia

[0028] 60 SD rats, provided by the Experimental Animal Center of Wenzhou Medical University, clean grade, weighing 200-250 g, aged 2-3 months. They were randomly divided into control group, low-dose catalpol group and high-dose catalpol group, with 20 rats in each group. Rats were anesthetized by intraperitoneal injection of 2% pentobarbital sodium (40mg / Kg), and the limbs and teeth were fixed in prone position. After the anesthesia took effect, the hair on the back trunk of the rat was preliminarily shaved with a shaver, the unremoved hair was moisturized with distilled water, and the depilatory cream was evenly applied. After waiting 3 minutes, gently remove the cream with a plastic sheet and repeat the process until the hair is completely removed. Design a modified McFarlane flap whose longitudinal axis is parallel to the long axis of the back of the rat and whose size is 3 cm × 9 cm, with the line co...

Embodiment 3

[0030] Example 3: Detection of skin flap survival area ratio and skin flap survival status

[0031] Flap Survival Area Ratio and Flap Survival Condition Detection 1-7 days after operation, the color, texture, tissue elasticity, and hair growth or necrosis of rats were observed with the naked eye. Seven days after operation, the rats were anesthetized with 100 g / L chloral hydrate (8 mL / kg) and sacrificed. The surviving area of ​​the flap and the total flap area of ​​the rat were accurately traced and cut with transparent paper, and the mass was weighed with an electronic scale. Calculate the percentage of flap survival area [flap survival area transparent paper mass ÷ total flap surface area transparent paper mass × 100%]. Each rat was measured twice, and the average value was taken. The surviving area is pink, soft in texture, and has new hair growth; the necrotic area is black in color of the flap, the tissue retracts, has poor elasticity, and is hard in texture, and the cut...

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Abstract

The invention relates to an effect of catalpol in preparation of a medicine for promoting ischemic random flap survival, in the process of promoting ischemic random flap survival, an intravenous injection mode is adopted, a conclusion is drawn through a large number of animal experiments, the survival area ratio of flaps can be obviously increased by using catalpol, and the survival rate of the flaps can be obviously increased by using catalpol. The survival of ischemic random skin flaps can be well promoted.

Description

technical field [0001] The invention relates to a new application of catalpol, in particular to the role of catalpol in the preparation of drugs for promoting the survival of ischemic ultra-long random skin flaps. Background technique [0002] In recent years, with the continuous improvement of my country's economic level, industries such as industry and energy have shown a trend of rapid development, and the resulting cases of large-area trauma and tissue defects related to occupations and traffic behaviors are also increasing. This type of trauma usually leaves different degrees of deformity and dysfunction after repair, especially trauma deformity of the hands and face. As patients' requirements for perfect appearance and functional recovery are increasing day by day, the repair technology and treatment methods for wound problems have become an important consideration in medicine. Skin flap repair is a common surgical intervention method for repairing wounds, reconstruct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K36/804A61K9/00A61P17/02
CPCA61K31/7048A61K36/804A61K9/0019A61P17/02
Inventor 林丁盛马心怡林毅方妙杰
Owner THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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