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Application of trehalose in preparation of medicines for promoting survival of extra-long random flap

A technology of trehalose and promotion is applied in the application field of trehalose in the preparation of a drug for promoting the survival of super-long random skin flaps, and can solve the problems of affecting the survival of random skin flaps and the like

Inactive Publication Date: 2019-08-30
THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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Problems solved by technology

Recent studies have found that trehalose has multiple biological activities: trehalose can induce the activation of autophagy to promote cardiac remodeling after myocardial ischemic infarction; neuronal cell death in the treatment of neurodegenerative diseases; however, there is no report that trehalose can affect the survival of random skin flaps

Method used

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  • Application of trehalose in preparation of medicines for promoting survival of extra-long random flap
  • Application of trehalose in preparation of medicines for promoting survival of extra-long random flap
  • Application of trehalose in preparation of medicines for promoting survival of extra-long random flap

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Embodiment Construction

[0023] Trehalose can significantly improve the survival of ultra-long ischemic random flaps. In the process of promoting the survival of ischemic random skin flaps, intraperitoneal injection is adopted, and every gram of trehalose is dissolved in 1 ml of normal saline to make a 1g / ml solution. The method of use is intraperitoneal injection of 2g per kilogram of mice per day Trehalose, 12 days before operation to 7 days after operation is a course of treatment. The following is the evaluation of the role of trehalose in promoting the survival of ischemic random flaps:

[0024] 1. Establishment of random flap model of ischemia

[0025] 90 healthy male C57BL / 6 mice were selected, provided by the Experimental Animal Center of Wenzhou Medical University, clean grade, SCXK[ZJ] 2005-0019, weighing 20-30g. The mice were randomly divided into 3 groups, 30 in the normal saline control group, 30 in the sucrose control group, and 30 in the trehalose experimental group. Using the modifi...

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Abstract

The invention discloses application of trehalose in preparation of medicines for promoting survival of an extra-long random flap. Specific application of trehalose adopts a mode of intraperitoneal injection, 1g / ml of solution is prepared by dissolving per 1g of trehalose in 1ml of normal saline. According to a use method of the trehalose, intraperitoneal injection is performed every day in a doseof 2g / kg, and each course of treatment lasts from 12 days before an operation to 7 days after the operation. Through the conclusion obtained from a large number of animal experiments, the surviving area of a flap can be remarkably increased by using the trehalose, and the survival of an extra-long random flap can be well promoted.

Description

technical field [0001] The invention relates to a new application of trehalose, in particular to the application of trehalose in the preparation of a drug for promoting the survival of superlong random skin flaps. Background technique [0002] In recent years, with the rapid development of industries such as industry, transportation, and construction, patients with large-scale injuries and tissue defects have become more and more common. After debridement, these patients often have skin and soft tissue defects, which cannot be sutured directly. Flap covered. Random flaps are widely used clinically because of their flexible application, convenient access, and good recovery. However, when the length-to-width ratio of random flaps exceeds 1.5:1, the poor blood supply at the distal end causes necrosis in varying degrees. This undoubtedly limits the clinical application of random flaps, so how to increase the survival of random flaps and reduce flap necrosis has become an impor...

Claims

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Application Information

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IPC IPC(8): A61K31/7016A61P17/00
CPCA61K31/7016A61P17/00
Inventor 周凯亮吴弘强盛诗敏丁健徐华梓
Owner THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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