Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Database establishing method and risk prediction method for genetic diseases

A genetic disease and method establishment technology, applied in health index calculation, medical informatics, informatics, etc., can solve the problems of no genetic risk assessment method, no complex disease variation database, etc., and achieve the effect of accurate risk prediction

Inactive Publication Date: 2018-06-15
上海其明信息技术有限公司
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of this, at present, there is no well-informed and comprehensive database of complex disease variants, and there is no method for genetic risk assessment

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Database establishing method and risk prediction method for genetic diseases
  • Database establishing method and risk prediction method for genetic diseases
  • Database establishing method and risk prediction method for genetic diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0021] Below, the structure and working principle of the present invention will be further described in conjunction with the accompanying drawings.

[0022] Such as figure 1 as shown, figure 1 It is a schematic flowchart of the method for establishing the database in the present invention, including: S1 establishing the first database based on the first data and the second data; usually, using mysql to establish the first database based on the first data and the second data.

[0023] S2 regularizes the first data and the second data;

[0024] S3 classify the first database according to the first attribute in the first database, and select the classified third data;

[0025] S4 combining the second data with the third data to generate integrated data;

[0026] S5 supplementing missing data in said integrated data;

[0027] In a preferred embodiment of the present invention, the regularization is specifically to use regular expressions and text processing packages of python ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a database establishing method and a risk prediction method for genetic diseases. The database establishing method comprises the following steps: a step of establishing a firstdatabase based on first data and second data; a step of classifying the first database according to a first attribute in the first database and selecting third data after classifying operation; a step of combining the second data and the third data to generate integrated data; a step of establishing a second database according to the integrated data. According to the database establishing methodand the risk prediction method for the genetic diseases, a genetic disease variation database is built, and the risk prediction method for the genetic diseases is built based on combination of the genetic disease variation database and a weighted GRS method and a Bayesian formula. Accurate prediction of the risk of the genetic diseases is achieved while recorded information and texts of the genetic disease variation database are standardized.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a method for establishing a database and a risk prediction method for genetic diseases. Background technique [0002] At present, the inheritance of complex diseases, such as gastric cancer and colon cancer, does not follow the Mendelian inheritance model, and its occurrence is affected by multiple minor genes and environmental factors. Complex diseases are widespread worldwide and seriously endanger human health. People are eager to find the pathogenesis of these diseases fundamentally, so as to provide the basis and guarantee for the diagnosis, treatment and prevention of diseases. In the past decade, with the development of high-throughput molecular detection technology, many disease-related gene mutation sites have been discovered, especially the development of genome-wide association study (GWAS) technology, which has accelerated the pace of research on common and complex human ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G16H50/30
Inventor 王东梅李奇
Owner 上海其明信息技术有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com