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Application of limonin extracts to preparation of diabetes treatment medicine

A technology of limonoids and diabetes drugs, applied in the field of biomedicine, can solve problems such as limonin extracts that have not yet been seen, and achieve remarkable curative effect

Inactive Publication Date: 2018-06-29
JINAN HAOYU QINGTIAN PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no relevant literature or patent reports on limonoid extracts from neem leaves and Toona sinensis leaves

Method used

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  • Application of limonin extracts to preparation of diabetes treatment medicine
  • Application of limonin extracts to preparation of diabetes treatment medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: Preparation of limonoid extract

[0027] (1) Take 3 kg of neem leaves and 1 kg of Chinese toon leaves, mix them evenly, crush them, pass through a 20-mesh sieve, use petroleum ether as a solvent, and extract twice at 50°C, each extraction time is 3 hours, and the amount of each solvent is neem leaves and 12 times of the total weight of Chinese toon leaves, filtered, combined petroleum ether extracts, reclaimed petroleum ether under reduced pressure, concentrated and dried to obtain crude extract A, and the medicinal residue after petroleum ether extraction is for subsequent use;

[0028] (2) Extract the dregs after petroleum ether extraction in step (1) with ethyl acetate-methanol mixed solvent with a volume ratio of 1:6, and extract three times at 70°C, each extraction time is 2 hours, and the amount of solvent used each time is 10 times the total weight of neem leaves and Chinese toon leaves, filter, combine the ethyl acetate-methanol extracts, recover t...

Embodiment 2

[0034] Embodiment 2: the preparation of limonoid extract

[0035] (1) Take 2kg of neem leaves and 1kg of Chinese toon leaves, mix them evenly, crush them, pass through a 20-mesh sieve, use petroleum ether as a solvent, and extract twice at 50°C, each extraction time is 3 hours, and the amount of each solvent is neem leaves and 12 times of the total weight of Chinese toon leaves, filtered, combined petroleum ether extracts, reclaimed petroleum ether under reduced pressure, concentrated and dried to obtain crude extract A, and the medicinal residue after petroleum ether extraction is for subsequent use;

[0036] (2) Extract the dregs after petroleum ether extraction in step (1) with ethyl acetate-methanol mixed solvent with a volume ratio of 1:5, and extract three times at 70°C, each extraction time is 2 hours, and the amount of solvent used each time 10 times the total weight of neem leaves and Chinese toon leaves, filter, combine the ethyl acetate-methanol extracts, recover th...

Embodiment 3

[0042] Embodiment 3: the preparation of limonoid extract

[0043] (1) Take 1 kg of neem leaves and 3 kg of Chinese toon leaves, mix them evenly, crush them, pass through a 20-mesh sieve, use petroleum ether as a solvent, and extract twice at 50°C, each extraction time is 3 hours, and the amount of each solvent is neem leaves and 12 times of the total weight of Chinese toon leaves, filtered, combined petroleum ether extracts, reclaimed petroleum ether under reduced pressure, concentrated and dried to obtain crude extract A, and the medicinal residue after petroleum ether extraction is for subsequent use;

[0044] (2) Extract the dregs after petroleum ether extraction in step (1) with a mixed solvent of ethyl acetate-methanol at a volume ratio of 1:3, and extract three times at 70°C, each extraction time is 2 hours, and the amount of solvent used each time 10 times the total weight of neem leaves and Chinese toon leaves, filter, combine the ethyl acetate-methanol extracts, recov...

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Abstract

The invention discloses a preparation method of limonin extracts and application of the limonin extracts to preparation of diabetes treatment medicine. The limonin extracts are prepared by the following method that szechwan chinaberry leaves and folium toonae sinensis are used as raw materials to be extracted, separated and purified to obtain the limonin extracts consisting of aphanamixoid C, aphanamixoid C and chukvelutilide K. The limonin extracts provided by the invention have the important significance on the preparation of diabetes treatment medicine.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to the application of a limonoid extract in the preparation of a drug for treating diabetes, in particular to the application of a limonoid extract in the leaves of Neem and Toona sinensis in the preparation of a drug for treating diabetes. Background technique [0002] Diabetes mellitus is a metabolic disease caused by insufficient insulin secretion or insensitivity of peripheral tissues to insulin. etc.) long-term impairment, insufficiency or failure. According to different pathogenesis, diabetes can be divided into type Ⅰ diabetes, type Ⅱ diabetes, gestational diabetes and other types of diabetes. [0003] According to statistics, in 2015, about 415 million people aged 20-79 in the world suffered from diabetes (8.8% prevalence rate), and another 318 million people had impaired glucose tolerance (pre-prevalence rate was 6.7%). China is the country with the largest number of diabetic pat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/58A61P3/10A61K127/00
CPCA61K36/58A61K2236/331A61K2236/333A61K2236/35A61K2236/39A61K2236/55A61K2300/00
Inventor 不公告发明人
Owner JINAN HAOYU QINGTIAN PHARMA TECH CO LTD
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