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Application of magnetic field constraint equipment in preparation of product for inhibiting tumor metastasis

A technology of tumor metastasis and equipment, which is applied in the field of biophysics, can solve the problems of not being able to significantly inhibit tumor metastasis, have no extremely weak magnetic field, and reduce the degree of malignancy of tumors, and achieve the effects of simple non-invasive treatment environment, reduction of malignancy, and convenient treatment

Inactive Publication Date: 2018-08-28
INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More importantly, although chemotherapy and radiotherapy can effectively block the proliferation and metabolic process of tumor cells, chemotherapy drugs cannot significantly inhibit tumor metastasis and reduce tumor malignancy.
At present, there is no research on the application of extremely weak magnetic fields in tumor therapy

Method used

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  • Application of magnetic field constraint equipment in preparation of product for inhibiting tumor metastasis
  • Application of magnetic field constraint equipment in preparation of product for inhibiting tumor metastasis
  • Application of magnetic field constraint equipment in preparation of product for inhibiting tumor metastasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1. Magnetic field confinement inhibits the migration of 4T1 cells

[0034] Test cells: 4T1 cells, a mouse breast cancer cell line. It can be purchased from Concord Cell Bank and ATCC Cell Bank in the United States.

[0035] 1. Experimental grouping and methods

[0036] They were divided into magnetic field confinement group and geomagnetic field control group.

[0037] 1.1 Magnetic field conditions:

[0038] Magnetic field confinement group: use magnetic field confinement equipment to control the magnetic field strength in the environment to 0.1-0.5μT.

[0039] Geomagnetic field control group: the magnetic field environment is 40μT, which is the same as the geomagnetic field in Beijing.

[0040] The cells of the magnetic field confinement group were cultured in a magnetic field confinement device. The geomagnetic field control group was cultured outside the magnetic field confinement device. The two groups of cells were kept in the same cell culture box ( ...

Embodiment 2

[0063] Example 2. Magnetic field confinement inhibits lung metastasis of 4T1 solid tumors

[0064] Test cells: 4T1 cells, a mouse breast cancer cell line.

[0065] Test animals: Balb / c mice. The animals were provided by the Animal Room of Tumor Hospital, Academy of Medical Sciences. Mice of the exact same strain can be purchased commercially (Virtual Liver).

[0066] 1. Experimental method

[0067] (1) Preparation of 4T1 breast cancer solid tumor advanced lung metastasis animal model

[0068] Prepare a saline suspension of 4T1 cells at a concentration of 2 million cells / ml. Inject 100 microliters of 4T1 cell suspension into the fourth nipple pad of the left abdomen of the mouse, with an injection volume of 200,000 cells. After injection, the mice were acclimatized in the experimental environment for 1 day.

[0069] (2) Experimental grouping

[0070] Mice were randomly divided into cages according to 5 mice / cage. Three cages were raised respectively in the geomagnetic f...

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Abstract

The invention discloses a new function of magnetic field constraint equipment. The new function is specifically that the magnetic field constraint equipment is applied to A) preparation of a product for inhibiting tumor metastasis, and B) preparation of a product for inhibiting tumor cell migration. Experiments prove that under a magnetic field constraint condition (0-5 muT), migration ability ofbreast cancer cells and metastasis of breast cancer solid tumors are inhibited obviously; the magnetic field constraint condition is a physical environment that is easy to simulate, so that treatmentof tumours can be realized very conveniently; and since a magnetic field can penetrate biological tissue, noninvasive treatment can be realized. The method not only can reduce malignant grade of tumours, but also can provide a simple and non-invasive treatment environment.

Description

technical field [0001] The invention belongs to the field of biophysics and relates to the application of magnetic field confinement equipment in the preparation of products for inhibiting tumor metastasis. Background technique [0002] Tumors develop when normal cells proliferate out of control. Malignant tumors are diagnosed when they exhibit features such as destructive growth, invasiveness, and metastases. Tumor invasion can severely damage surrounding tissues and organs. It specifically destroys the basal layer surrounding the tissue, resulting in a localized spread of tumor cells. Tumor cells often spread through the circulatory system. Tumor metastasis means the spread of tumor cells from the original site to other organs through the lymphatic or blood circulatory system. In a broad sense, the spread and spread of tumor cells in the body cavity is also tumor metastasis. A tumor's ability to metastasize determines its malignancy. [0003] At present, surgery, rad...

Claims

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Application Information

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IPC IPC(8): A61N2/00
CPCA61N2/00A61N2/004
Inventor 莫炜川胡平东刘缨赫荣乔
Owner INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES
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