Method and device for manufacturing one-time molded tissue chip receptor wax piece

Abstract

The invention discloses a device for manufacturing a one-time molded tissue chip receptor wax piece. The device comprises a rectangular recess cofferdam, an array grid guide hole structure and a columnar array grid, wherein a recess hole is formed in the rectangular recess cofferdam; the array grid guide hole structure is matched with the columnar array grid; the array grid guide hole structure ismoved in an up and down straight line manner on a columnar matrix of the columnar array grid through a lifting device; the array grid guide hole structure, the column matrix of the columnar array grid and the recess hole above form a cofferdam type wax holding mold cavity with the array grid guide hole structure as a bottom. By adopting the device, an axial position of the columnar array grid canbe effectively confirmed, on the basis of one-time molding, a hole drilling depth can be strictly controlled, strict control on precision can be achieved, and problems that in the prior art, breakage, burring, cracking and large batch differences in a receptor wax piece manufacturing process can be solved.

Description

technical field [0001] The invention relates to an important experimental method and device in the field of biomedicine, which is used for preparing a once-formed tissue chip acceptor wax block, and belongs to the technical field of tissue chip production. Background technique [0002] Tissue chip technology (tissue chip), also known as tissue microarray (tissue microarray, TMA), can orderly arrange dozens to hundreds of tiny pathological tissues on a glass slide, and then make high-throughput pathological tissues slice. In recent years, tissue chip technology is another biochip technology emerging after gene chips and protein chips, which can be used to study the expression of the same gene or protein in different cells or pathological tissues, and the relationship between it and clinical characteristics. It has many advantages such as high throughput, large sample, high efficiency, and low cost. At the same time, it can reduce the damage to the original tissue wax block a...

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Problems solved by technology

Moreover, the only imported prefabricated receptor wax block currently on sale in the world is extremely expensive (about 600 yuan / piece), and the self-made wax block lacks uniform standards and devices, and there are cumbersome steps in production, poor quality, and batch production. These shortcomings make the development and application of tissue chip technology face great restrictions, and restrict the promotion and application of tissue chip technology.

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