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Method for immunizing cattle by brucella vaccine and application of method

A technology of Brucella and Brucella bovis, which is applied in the field of vaccines, can solve the problems of high infection risk, inability to play a protective role, bovine side effects and other problems of immunization operators, so as to reduce the risk of Brucella infection , Strengthen the immune memory of the body, and enhance the safety of personnel

Inactive Publication Date: 2018-11-16
TECON BIOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of live vaccines has many disadvantages: first, animals tend to have more severe stress reactions after inoculation with live vaccines; Risk of infection; third, the immune effect of a live vaccine may not be good
At present, the Brucella vaccines suitable for cattle mainly include A19 and S2, among which A19 is more virulent, and the dosage for immunizing cattle is relatively large, usually 60-80 billion CFU / head, so it is easy for the immunized cattle Cause toxic and side effects, and easily infect the vaccinators; S2 vaccine has poor immunogenicity and cannot play a good protective role

Method used

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  • Method for immunizing cattle by brucella vaccine and application of method
  • Method for immunizing cattle by brucella vaccine and application of method
  • Method for immunizing cattle by brucella vaccine and application of method

Examples

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Effect test

Embodiment 1

[0054] Present embodiment provides a kind of method of brucella vaccine immune cattle, comprises the steps:

[0055] (a) First immunization: immunize against Brucella bovine vaccine A19 vaccine, subcutaneously inoculate 10 billion CFU / head;

[0056] (b) Secondary immunization: Inactivate the Brucella bovine vaccine A19 with formaldehyde, and immunize cattle with the inactivated Brucella bovine vaccine A19 25 days after the first immunization, with a dosage of 50 billion CFU / The first serving is calculated according to the number of live bacteria before the vaccine is inactivated.

Embodiment 2

[0058] Present embodiment provides a kind of method of brucella vaccine immune cattle, comprises the steps:

[0059] (a) First immunization: immunize against Brucella bovine vaccine A19 vaccine, subcutaneously inoculate 9 billion CFU / head;

[0060] (b) Secondary immunization: inactivate the Brucella bovine vaccine A19 with formaldehyde, and immunize cattle with the inactivated Brucella bovine vaccine A19 30 days after the first immunization, with a dosage of 48 billion CFU / The first serving is calculated according to the number of live bacteria before the vaccine is inactivated.

Embodiment 3

[0062] Present embodiment provides a kind of method of brucella vaccine immune cattle, comprises the steps:

[0063] (a) First immunization: immunize against Brucella bovis vaccine A19 vaccine, subcutaneously inoculate 11 billion CFU / head;

[0064] (b) Secondary immunization: Inactivate the Brucella bovine vaccine A19 with formaldehyde, and immunize cattle with the inactivated Brucella bovine vaccine A19 20 days after the first immunization, with a dosage of 50 billion CFU / The first serving is calculated according to the number of live bacteria before the vaccine is inactivated.

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Abstract

The invention provides a method for immunizing cattle by a brucella vaccine and an application of the method, and relates to the technical field of vaccines. The method for immunizing the cattle by the brucella vaccine comprises the following steps: firstly immunizing the cattle once by using a vaccine A, and immunizing the cattle at least once by using a vaccine B, wherein the vaccine A is a brucella live vaccine, and an immunizing amount is 60 hundred million to 150 hundred million CFU / each cattle; and the vaccine B includes at least one of an inactivated vaccine, subunit vaccine, recombinant protein vaccine, polypeptide vaccine and DNA vaccine of brucell. According to the method provided by the invention, in primary immunization, the live vaccine with a low dose is used to immunize andactivate humoral and cellular immunity of a body, then the non-live vaccine is used for secondary or more immunization of the body, so that immune memory of the body can be strengthened, a stress reaction of the cattle and infection risk of operators can be reduced while effective protection is provided, and the technical problems that the prior art lacks a method which is safe to humans and can effectively immunize the cattle for immunizing the cattle by the brucella vaccine are alleviated.

Description

technical field [0001] The invention relates to the technical field of vaccines, in particular to a method and application of a Brucella vaccine for immunizing cattle. Background technique [0002] Brucellosis (Brucellosis, referred to as Brucellosis), also known as Mediterranean relaxation fever, Malta fever or wave fever, is a disease caused by Brucella with a wide range of epidemics and seriously endangers the health of humans and animals. Infectious-allergic diseases. Brucella (Brucella) is a Gram-negative short rod-mounted bacterium that grows in a single arrangement, rarely in pairs, short chains or strings, has no flagella, does not form spores or capsules, and does not sports. Animals infected with brucellosis generally have symptoms such as miscarriage, infertility, orchitis, and joint inflammation. The clinical characteristics of human infection are mostly persistent infection, heat waves, hyperhidrosis, arthralgia, etc., and may recur or leave severe symptoms. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/02
CPCA01K67/02
Inventor 贺笋何传雨李延涛任立松赵海龙候枫刘梦志刘鸽
Owner TECON BIOLOGY CO LTD
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