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Application of pteris vittata extract in preparation of medicament for treating Alzheimer's disease

A technology of Alzheimer's disease and centipede grass, which is applied in the field of application of centipede grass extract in the preparation of drugs for the treatment of Alzheimer's disease, and can solve problems such as less research

Inactive Publication Date: 2018-11-16
JINGGANGSHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on Centipede Grass at home and abroad mainly focuses on arsenic enrichment and environmental management, while the research on the effective components of Centipede Grass mainly focuses on the convenience of extracting total flavonoids from Centipede Grass and the antioxidant activity of Centipede Grass. There are few studies on extracting other active ingredients from

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The acetylcholinesterase inhibitor is prepared by mixing the following substances: 10 parts of centipede grass extract, 5 parts of motherwort extract and 100 parts of auxiliary materials;

[0045] The motherwort extract is a mixture extracted from dried whole motherwort with an ethanol solution with a volume fraction of 95%. The specific preparation process is as follows: Weigh 0.65 kg of dried Motherwort whole herb, crush it, and extract it with 8 times the mass fraction of 95% ethanol solution at room temperature for 3 times, each time for 2 hours, filter and collect all the extracts, and extract The liquid is concentrated under reduced pressure to obtain the motherwort extract without ethanol smell, and then dried to obtain the motherwort extract.

[0046]Centipede herb extract is prepared according to the following method:

[0047] (1) Take by weighing 1.3kg of the dry whole herb of Centipede Grass, crush it and extract it 3 times at room temperature with an ethano...

Embodiment 2

[0056] The acetylcholinesterase inhibitor is prepared by mixing the following substances: 20 parts of centipede grass extract, 10 parts of motherwort extract and 300 parts of auxiliary materials;

[0057] The motherwort extract is a mixture extracted from dried whole motherwort with an ethanol solution with a volume fraction of 95%.

[0058] Wherein the preparation method of Motherwort extract is the same as in Example 1;

[0059] The auxiliary material is a mixture of microcrystalline cellulose, corn starch and talcum powder in a mass ratio of 1:5:0.3.

Embodiment 3

[0061] The acetylcholinesterase inhibitor is prepared by mixing the following substances: 15 parts of centipede grass extract, 7 parts of motherwort extract and 200 parts of auxiliary materials;

[0062] The motherwort extract is a mixture extracted from dried whole motherwort with an ethanol solution with a volume fraction of 95%.

[0063] Wherein the preparation method of Motherwort extract is the same as in Example 1;

[0064] The auxiliary material is a mixture of microcrystalline cellulose and corn starch in a mass ratio of 1:4.

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Abstract

The invention discloses application of a pteris vittata extract in preparation of a medicament for treating Alzheimer's disease. The medicament for treating Alzheimer's disease is an acetylcholinesterase inhibitor. Chemical components of the pteris vittata extract comprise apigenin, apigenin-7-O-beta-D-glucoside, luteolin, luteolin-7-O-beta-D-glucose, kaemperfol-3-O-beta-D-glucoside and beta-sitosterol. The acetylcholinesterase inhibitor is prepared by mixing the following substances (by weight): 10-20 parts of the pteris vittata extract, 10-20 parts of a motherwort extract and 100-300 parts of accessories. In comparison with the prior art, the invention has the following beneficial effects: the inhibition rate of various chemical components in the pteris vittata extract in inhibiting acetylcholinesterase can reach 28.9-85.1%, and an active lead structure with a certain value is provided for the research on drugs for preventing and treating Alzheimer's disease.

Description

technical field [0001] The invention belongs to the technical field of application of Chinese herbal medicines, in particular to the application of centipede herb extracts in the preparation of medicaments for treating Alzheimer's disease. Background technique [0002] Alzheimer's disease (also known as Alzheimer's disease, Alzheimer's Disease, AD) is a brain degenerative disease that occurs in old age and early old age and is characterized by progressive neurodegeneration. It is a degenerative disease of the central nervous system. The clinical manifestations are progressive cognitive decline accompanied by behavioral disorders and emotional abnormalities, and severe cases until loss of self-care ability. Its safe and effective preventive and therapeutic drug research is currently a research hotspot in the field of pharmacy at home and abroad. Current studies believe that AD is a disease with multiple etiologies, and the cholinergic hypothesis is the most widely accepted p...

Claims

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Application Information

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IPC IPC(8): A61K36/12A61P25/28
CPCA61K36/12A61P25/28
Inventor 殷帅文朱立成
Owner JINGGANGSHAN UNIVERSITY
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