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Method for detecting whether retina is damaged or not

A detection method and retinal technology, applied in the detection field, can solve problems such as damage and the degree of retinal damage that has not yet been detected, and achieve the effects of reducing incidence, preventing glaucoma, and predicting glaucoma.

Inactive Publication Date: 2018-12-11
ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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AI Technical Summary

Problems solved by technology

[0008] At present, the level of intraocular pressure is mostly used as a reference for retinal damage in ocular hypertension in clinical practice, but high intraocular pressure at the same level may cause damage or may not cause damage. effective measure of damage

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  • Method for detecting whether retina is damaged or not
  • Method for detecting whether retina is damaged or not
  • Method for detecting whether retina is damaged or not

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Embodiment Construction

[0020] The method for detecting whether the retina is damaged in the present invention is used for detecting whether the retina is damaged.

[0021] refer to figure 1 , figure 2 , image 3 and Figure 4 A preferred embodiment of the method for detecting whether the retina is damaged in the present invention is described in detail.

[0022] In biomedicine, TUNEL method is a general method to detect retinal damage in non-living body.

[0023] TUNEL method is terminal dexynucleotidyl transferaseTdT-mediated dUTP nickend labeling, translated as terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay, also known as in situ end labeling of DNA fragmentation, this method can be used for DNA molecule fragmentation The 3'-OH in the gap is labeled in situ. With the help of an observable marker, such as fluorescein, the 3'-OH end generated in the nuclear DNA of apoptotic cells can be labeled in situ. Observation is possible.

[0024] In the retina injured by hi...

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Abstract

The invention provides a method for detecting whether a retina is damaged or not. The method is characterized in that whether the retina is damaged or not is detected by detecting whether a synaptic vesicle protein exists in aqueous humor or not, the synaptic vesicle protein is a synaptic vesicle protein 2, and whether the synaptic vesicle protein 2 exists in the aqueous humor or not is detected by using a synaptic vesicle protein 2 antibody. According to the method for detecting whether the retina is damaged or not, whether the retina is damaged or not is detected by detecting whether the synaptic vesicle protein 2 exists in the aqueous humor or not, the method is an effective method for clinically detecting the damage degree of the retina suffering from high intraocular pressure damage,the occurrence of glaucoma can be effectively predicted, and therefore a basis is provided for preventing the glaucoma, and the morbidity of the glaucoma is lowered.

Description

technical field [0001] The invention relates to a detection method, in particular to a detection method of whether the retina is damaged. Background technique [0002] It is generally believed that intraocular aqueous humor circulation disorder or some unknown eye diseases will lead to increased intraocular pressure, which will cause retinal damage to a certain extent, and glaucoma if damaged to a certain extent; therefore, increased intraocular pressure, retinal damage and glaucoma are In turn causality. [0003] Retinal damage is the result of elevated intraocular pressure and is also the cause of glaucoma. The time from elevated intraocular pressure to retinal damage may range from a few minutes to several days. The emergence of glaucoma symptoms is a slow process. Recognized glaucoma symptoms take at least a year and possibly longer. [0004] Common tests for glaucoma are: [0005] 1. Perimeter measurement, visible visual field is missing; [0006] 2. Optical coheren...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/6854A61B3/117G01N33/6893G01N2333/4703G01N2800/164G01N2800/32A61B3/13A61B3/16G01N33/564G01N2800/168
Inventor 唐仲书
Owner ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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