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Extracting method for hyoscyamine and scopolamine in prescription preparation

A technology of scopolamine and extraction method, which is applied in the field of extraction of traditional Chinese medicine components, can solve the problems of low content of scopolamine and scopolamine, difficulty in extraction, complex components, etc.

Active Publication Date: 2018-12-14
承德宇航人高山植物应用技术有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems that existing prescription preparations have complicated components, and the contents of hyoscyamine and scopolamine are low, and it is difficult to extract them, the invention provides a method for extracting hyoscyamine and scopolamine from prescription preparations

Method used

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  • Extracting method for hyoscyamine and scopolamine in prescription preparation
  • Extracting method for hyoscyamine and scopolamine in prescription preparation
  • Extracting method for hyoscyamine and scopolamine in prescription preparation

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Embodiment 1

[0034] The embodiment of the present invention provides a method for extracting hyoscyamine and scopolamine in a prescription preparation. The prescription preparation adopts Weitongning tablet, wherein the composition of Weitongning tablet includes: dandelion extract 300g, aluminum hydroxide 300g, licorice dry extract 210g, Tianxianzi extract 25g, gentian powder 155g, cumin oil 4mL, Tianxianzi extract contains hyoscyamine and scopolamine.

[0035] The extraction method of hyoscyamine and scopolamine in Weitongning tablets: comprises the following steps:

[0036] Step a, grind the Weitongning Tablets, sample 1.0 g, add 34 times the mass of ethanol with a volume concentration of 75%, ultrasonically extract 3 times, each time for 30 min, centrifuge, combine the supernatant, evaporate to dryness, and obtain the first residue;

[0037] Step b. Dissolve the first residue in an ammonia solution with a mass concentration of 2.16% that is 20 times the sampling mass, add chloroform tha...

Embodiment 2

[0061] The embodiment of the present invention provides a method for extracting hyoscyamine and scopolamine in a prescription preparation. The prescription preparation adopts Weitongning tablet, wherein the composition of Weitongning tablet includes: dandelion extract 300g, aluminum hydroxide 300g, licorice dry extract 210g, Tianxianzi extract 25g, gentian powder 155g, cumin oil 4mL, Tianxianzi extract contains hyoscyamine and scopolamine.

[0062] The extraction method of hyoscyamine and scopolamine in Weitongning tablets: comprises the following steps:

[0063] Step a, grind the Weitongning Tablets, sample 1.2g, add 40 times the mass of ethanol with a volume concentration of 70%, ultrasonically extract twice, each time for 35min, centrifuge, combine the supernatant, evaporate to dryness, and obtain the first residue;

[0064] Step b, dissolving the first residue in an ammonia solution with a mass concentration of 2.0% that is 22 times the sampling mass, adding chloroform tha...

Embodiment 3

[0069] The embodiment of the present invention provides a method for extracting hyoscyamine and scopolamine in a prescription preparation. The prescription preparation adopts Weitongning tablet, wherein the composition of Weitongning tablet includes: dandelion extract 300g, aluminum hydroxide 300g, licorice dry extract 210g, Tianxianzi extract 25g, gentian powder 155g, cumin oil 4mL, Tianxianzi extract contains hyoscyamine and scopolamine.

[0070] The extraction method of hyoscyamine and scopolamine in Weitongning tablets: comprises the following steps:

[0071] Step a, grind the Weitongning Tablets, sample 0.8g, add 30 times the mass of ethanol with a volume concentration of 80%, ultrasonically extract 3 times, each time for 25min, centrifuge, combine the supernatant, evaporate to dryness, and obtain the first residue;

[0072] Step b, dissolving the first residue in an ammonia solution with a mass concentration of 2.5% that is 17 times the sampling mass, adding chloroform t...

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Abstract

The invention relates to the technical field of extraction of traditional Chinese medicinal components, in particular to an extracting method for hyoscyamine and scopolamine in a prescription preparation. The extracting method at least comprises the following steps: sampling a prescription preparation, adding ethanol with the volume concentration of 70 to 80 percent, carrying out ultrasonic extraction, centrifuging, and evaporating supernate to dryness to obtain first residues; dissolving the first residues into an ammonia solution, adding trichloromethane for carrying out ultrasonic extraction, separating an extracting solution to obtain a trichloromethane solution, and evaporating the trichloromethane solution to dryness to obtain second residues; adding methanol with the volume concentration of 45 to 55 percent into the second residues, and carrying out ultrasonic extraction, thus obtaining an extracting solution containing the hyoscyamine and the scopolamine. According to the extracting method provided by the invention, the influence from other components in the prescription preparation is avoided; by organically combining different extracting and separating methods, the hyoscyamine and the scopolamine in the prescription preparation are extracted.

Description

technical field [0001] The invention relates to the technical field of extraction of traditional Chinese medicine components, in particular to a method for extracting hyoscyamine and scopolamine in a prescription preparation. Background technique [0002] Hyoscyamine, also known as hyoscine, is one of the belladonna alkaloids isolated from traditional Chinese medicines such as Tianxianzi and Dajinhua. Hyoscyamine has the function of relieving pain and spasm, and has a good effect on sciatica. Sometimes it is also used to treat epilepsy and seasickness. [0003] Scopolamine, a fatal overdose, is a scopolane-type alkaloid found in plants of the nightshade family. Scopolamine is an alkaloid with the strongest pharmacological effect in belladonna, which can be used to block parasympathetic nerves, and can also be used as a central nervous system inhibitor. Its hydrobromide is generally used clinically, which can be used for anesthesia, analgesia, It relieves cough and asthma, ...

Claims

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Application Information

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IPC IPC(8): C07D451/10
CPCC07D451/10
Inventor 马丽杨甲忠王冠蕾孟珊张征
Owner 承德宇航人高山植物应用技术有限责任公司
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