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CpG-oligodeoxynucleotide, immunogenic composition, and use thereof

一种寡脱氧核苷酸、组成物的技术，应用在CpG寡脱氧核苷酸、免疫组成物及其用途领域，能够解决成本等问题

Active Publication Date: 2019-04-09
NAT INST OF HEALTH REPRESENTED BY THE SEC OF THE DEPT OF HEALTH & HUMAN SERVICES NAT INST OF HEALTH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, different species express different types of TLRs, which can cause unnecessary costs in the development of different types of CpG-ODNs suitable for the corresponding species

Method used

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  • CpG-oligodeoxynucleotide, immunogenic composition, and use thereof
  • CpG-oligodeoxynucleotide, immunogenic composition, and use thereof
  • CpG-oligodeoxynucleotide, immunogenic composition, and use thereof

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Embodiment Construction

[0036] In order to facilitate the examiner to understand the technical features, content, advantages and effects of the present invention, the embodiments of the present invention, the description of the drawings and the table will be described in detail below. The diagrams are only used as examples and to supplement the contents of the manual, and are not used to limit the implementation of the present invention in any way, and are described here first.

[0037] The methods, preparations, and materials used in the present invention for implementation and verification of substantial effects will be described in detail below.

[0038] In the embodiment of the present invention, the head kidney cells and spleen cells of grouper are separated according to the following steps. In water containing 0.2g / L tricaine (Tricaine), the spot grouper and saddle grouper were anesthetized, and the head, kidney and spleen were aseptically removed. Then the organs were gently chopped and mixed with...

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Abstract

A CpG-oligodeoxynucleotide (CpG-ODN) includes one or more copies of the sequences of GTCGTT, one or more copies of the sequences of GTT and one or more copies of the sequences of TTTT, wherein at least one copy of the sequence of GTCGTT is encoded between the sequence of GTT and the sequence of TTTT. Further, an immune composition containing the CpG-ODN and its use in the preparation of medicaments for inducing an immune response and for the treatment or prevention of a host disease are also provided.

Description

Technical field [0001] The present invention relates to CpG-oligodeoxynucleotide (CpG-ODN), an immune composition containing the same, and a method for inducing an immune response by using the same. Specifically, it relates to a method for inducing a TLR9-activated immune response and / or A TLR-21-activated immune response and CpG-ODN containing GTCGTT fragments, an immune composition containing the same, and a method for inducing these immune responses. Background technique [0002] CpG-oligodeoxynucleotide (CpG-ODN) is a known immunomodulator with potential. It induces inflammatory cytokines and helper T cell 1 (Th1) polarized immune response, leading to co-existence in antigen presenting cells. The performance of stimulating molecules and increased activation of B cells, T cells, natural killer cells, and other immune cells. [0003] Generally, different CpG-ODNs have race-specific activities based on their composition and length. For example, CpG-1826 (SEQ ID NO: 4) containing...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/117A61K39/39A61P35/00A61P31/20A61P31/04A61P31/22A61P31/16A61P33/06
CPCA61K39/39C12N15/117A61K2039/55561C12N2310/17A61K31/7088A61K31/711Y02A50/30
Inventor 庄宗显叶大玮赖朝阳刘奕玲吕志豪
Owner NAT INST OF HEALTH REPRESENTED BY THE SEC OF THE DEPT OF HEALTH & HUMAN SERVICES NAT INST OF HEALTH
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