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Application of halofuginone in preparing drugs for treating and preventing ischemic heart diseases

A technique for halofuginone and heart disease, which is applied in the application field of halofuginone in the preparation of drugs for treating and preventing ischemic heart disease, and can solve problems such as injury, myocardial cell ferroptosis, myocardial damage and the like

Inactive Publication Date: 2019-05-31
重庆赛拜欧生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Excessive oxygen free radicals can oxidize the lipid components on the cell membrane, cause lipid peroxidation, and cause cell membrane dysfunction and damage; at the same time, with the particip

Method used

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  • Application of halofuginone in preparing drugs for treating and preventing ischemic heart diseases
  • Application of halofuginone in preparing drugs for treating and preventing ischemic heart diseases
  • Application of halofuginone in preparing drugs for treating and preventing ischemic heart diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Protective Effect of Hemosanone on Cardiac Ischemia-Reperfusion Injury in Rats

[0022] 40 male SD rats, weighing 250-280g, were divided into sham operation group (group 1), solvent control group (group 2), low-dose hemosanone group (group 3), middle-dose hemosanone group (group 4), Huoshanone high-dose group (group 5). 8 rats in each group. The high, medium and low dose groups of hemosanone were administered at doses of 0.2 mg / kg, 0.1 mg / kg and 0.05 mg / kg, respectively. After the rats were weighed, 10% chloral hydrate was injected intraperitoneally at 3 mL / kg, fixed in a supine position after anesthesia, linked to electrocardiogram monitoring, tracheal intubation and connected to a ventilator (frequency: 75 times / min; tidal volume: 8-9 mL; Inhale: exhale=1:2), make a longitudinal incision on the 3rd-5th intercostal space beside the left border of the sternum, cut open and stir up the pericardium, expose the heart, and use the anterior left coronary artery a...

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Abstract

The invention provides application of halofuginone in preparing drugs for treating and preventing myocardial ischemia heart diseases. It is proved that the halofuginone has the good activity of preventing and treating the myocardial ischemia heart diseases. Particularly, the invention relates to application of the halofuginone in protecting cardiomyocyte injuries induced by hypoxia reoxygenation and protecting myocardial tissue injuries induced by ischemia reperfusion.

Description

technical field [0001] The invention belongs to the technical field of medicine, and more specifically, the invention relates to the application of hemosanone in the preparation of medicines for treating and preventing ischemic heart disease. Background technique [0002] Ischemic heart disease (also known as coronary heart disease, coronary artery heart disease, CHD) is a clinically common multiple cardiovascular disease, and its incidence rate ranks first among primary heart diseases, because of its high incidence and The fatality rate is a serious threat to human life and health. Restoring blood perfusion has become the basic principle in the treatment of ischemic diseases. With the wide application of thrombolysis, interventional surgery, coronary artery bypass grafting, heart transplantation and other treatment techniques, CHD has been alleviated and treated to a certain extent. However, while effectively opening the blood vessels, reducing the size of myocardial infar...

Claims

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Application Information

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IPC IPC(8): A61K31/517A61P9/10
Inventor 陈国庆黄健陈宇
Owner 重庆赛拜欧生物医药科技有限公司
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