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Application of GALNT2 as biomarker in diagnosis and/or treatment of glioma

A glioma and drug technology, applied in the field of medicine, can solve problems that have never been reported before, and achieve the effect of ensuring accuracy and stability, inhibiting cell proliferation and strong specificity

Active Publication Date: 2019-05-31
山东华链医疗科技有限公司
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, the function of GALNT2 has never been reported in glioma cells

Method used

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  • Application of GALNT2 as biomarker in diagnosis and/or treatment of glioma
  • Application of GALNT2 as biomarker in diagnosis and/or treatment of glioma
  • Application of GALNT2 as biomarker in diagnosis and/or treatment of glioma

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Experimental program
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Embodiment

[0076] (1) Materials and methods

[0077] 1. Clinical specimens and TCGA database

[0078] The clinical specimens were from patients undergoing neurosurgery (n=30) at Qilu Hospital of Shandong University, and were embedded in paraffin. Normal brain tissue samples (n=5) were collected from patients with severe craniocerebral injury undergoing partial resection and decompression therapy. mRNA expression microarray data and accompanying clinical information (n = 631) of samples in The Cancer Genome Atlas were analyzed using TCGA.

[0079] 2. Cox proportional hazards model

[0080] Cox proportional hazards models were used to select genes associated with patient survival and to build a predictive model for future predictions. Time to outcome was defined as overall survival and disease-free survival. Select N genes to build a Cox regression model, and each gene Gj (j=1, 2, ..., N), establishes the following Cox model.

[0081]

[0082] where is the baseline risk function of...

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Abstract

The invention belongs to the field of medicine, and particularly relates to application of GALNT2 as a biomarker in the treatment and / or prognosis of glioma. GALNT2 promotes malignant progression of the glioma by affecting O-type glycosylation and phosphorylation of EGFR and affecting the downstream PI3K / Akt passage. Therefore, GALNT2 can serve as the novel biomarker and a potential target for future glioma treatment.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to the application of GALNT2 as a biomarker in the treatment and / or prognosis of glioma. Background technique [0002] Gliomas account for 80% of intracranial primary tumors and are the most prevalent and lethal primary central nervous system tumors. Current multimodal treatment options include maximal surgical resection, radiotherapy, and chemotherapy. However, treatment outcomes measured by overall survival and quality of life are still unsatisfactory. Co-deletion of 1p / 19q, methylation of O6 methylguanine methyltransferase (MGMT) gene promoter, mutation / amplification of epidermal growth factor receptor (EGFR), isocitrate dehydrogenase 1 (IDH1 ) gene mutations and other genomic changes have been confirmed to be closely related to the tumorigenesis of glioma. However, there is still a lack of effective treatments and prognostic markers for glioma. Therefore, mining new glioma...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/11A61K31/7105A61P35/00
Inventor 李刚薛皓孙中正魏艳邓林
Owner 山东华链医疗科技有限公司
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