Tumor-associated antigen XAGE-1b nonapeptide and application thereof

A technology of xage-1b, 1.xage-1b, applied in the field of tumor-associated antigen XAGE-1b short peptide and its application, can solve the problems of further improvement of experimental data, unsatisfactory results, poor specificity, etc., and achieve The effect of good clinical translation and practical application prospects

Inactive Publication Date: 2019-07-05
广州美萨生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the technical scheme disclosed by CN102428102A, an attempt is made to intercept a part of the XAGE-1b antigen to induce humoral immunity or cellular immunity to the tumor, but the result is not satisfactory, and the length of the polypeptide is still not shorter than 16AA
Short peptides may also have the problem of poor specificity. How...

Method used

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  • Tumor-associated antigen XAGE-1b nonapeptide and application thereof
  • Tumor-associated antigen XAGE-1b nonapeptide and application thereof
  • Tumor-associated antigen XAGE-1b nonapeptide and application thereof

Examples

Experimental program
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Effect test

Embodiment Construction

[0027] XAGE-1b short peptide, its sequence is RQKKIRIQL.

[0028]Application of XAGE-1b short peptide in inducing and preparing tumor-specific cytotoxic T cell clone, wherein the XAGE-1b short peptide sequence is RQKKIRIQL.

[0029] A method for inducing tumor-specific cytotoxic T cells. The XAGE-1b short peptide whose sequence is RQKKIRIQL is presented by dendritic cells and co-cultured with CD8+ T cells, and induced and screened to obtain tumor-specific cytotoxic T cells.

[0030] A tumor polypeptide vaccine is composed of active antigen components and adjuvants, and the active antigen components are XAGE-1b short peptides whose sequence is RQKKIRIQL.

[0031] A DC vaccine for tumor treatment, which is mainly obtained by loading the XAGE-1b short peptide with the sequence RQKKIRIQL and dendritic cells.

[0032] The application of the XAGE-1b short peptide in the preparation of a non-small cell lung cancer diagnostic kit, wherein the sequence of the XAGE-1b short peptide is ...

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Abstract

The invention discloses tumor-associated antigen XAGE-1b nonapeptide and application thereof. The sequence of XAGE-1b oligopeptide is RQKKIRIQL. CTLs (cytotoxic T lymphocytes) induced by the XAGE-1b antigen peptide do not produce immune responses to testicular cells, but only kill tumor cells. Induced CTL clones have a good tumor cell specificity lethal effect. In the process of establishing the CTLs, the XAGE-1b antigen peptide screened out by the inventor has proper affinity with HLAs (human leukocyte antigens) on DC cells and can effectively stimulate and induce the specific CTLs, thereby having a good potential of serving as a polypeptide vaccine and a DC vaccine. Virus carriers are created by cloning specific TCR (T cell receptor) genes of the XAGE-1b antigen peptide, and peripheral circulation CD8+T cells are transduced to obtain clones of TCR gene modified T cells (TCR-T); the clones also have the tumor cell specificity lethal effect same as the parental CTLs, thereby having a good prospect in clinical transformation and practical application.

Description

technical field [0001] The invention relates to tumor-associated antigen peptides and applications thereof, in particular to tumor-associated antigen XAGE-1b short peptides and applications thereof. Background technique [0002] As we all know, T cell adoptive therapy for tumors is currently the most eye-catching technology, especially the application of receptor-engineered T cells (TCR-T) is becoming an exciting cancer treatment method, and it also has therapeutic effects on viral infections and autoimmune diseases. Wide application prospects. [0003] The human immune surveillance system plays an important role in the process of resisting tumor growth. The immune surveillance system achieves the purpose of inhibiting tumor growth by coordinating various types of immune cells, among which cytotoxic T cells (cytotoxic Tlymphocytes, CTLs) play an extremely important role and are the most important. Key killer effector cells. tumor antigen-specific CD8 + T cells can specifi...

Claims

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Application Information

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IPC IPC(8): C07K14/47C12N5/0783C12N5/0784A61K39/00A61P35/00G01N33/68G01N33/574
CPCA61K39/0011A61K2039/5154A61P35/00C07K14/4748C12N5/0638C12N2502/1121G01N33/57423G01N33/57484G01N33/68G01N2333/47
Inventor 张蓓
Owner 广州美萨生物科技有限公司
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