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Application of tumor-derived IgG in diagnosis or prognosis of pancreatic cancer

A technology for use and prognosis, applied in the fields of medicine, clinical diagnosis, and prognosis, which can solve the problems of lack of molecular prognostic markers

Active Publication Date: 2019-07-05
PEKING UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, accurate and effective molecular prognostic markers for pancreatic cancer are still lacking[6-8]

Method used

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  • Application of tumor-derived IgG in diagnosis or prognosis of pancreatic cancer
  • Application of tumor-derived IgG in diagnosis or prognosis of pancreatic cancer
  • Application of tumor-derived IgG in diagnosis or prognosis of pancreatic cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0062] The following trials were reviewed by the Ethics Committee of Peking Union Medical College Hospital of the Chinese Academy of Medical Sciences and abided by the Declaration of Helsinki. All patients were informed of the purpose of sample collection and storage and signed a written consent form.

[0063] 1. Case and trial design

[0064] Included in the pathological examination of 326 patients who had undergone radical surgery and were diagnosed as pancreatic ductal adenocarcinoma with tumor and paracancerous tissue specimens. The pathological diagnosis and staging standards refer to the seventh edition of the American Cancer Society Cancer Staging Manual.

[0065] The exclusion criteria included: preoperative chemotherapy and radiotherapy, perioperative death, receiving chemotherapy regimens other than gemcitabine and S1, and lack of follow-up data. Through age and gender matching, 326 cases were stratified and randomly divided into training set and validation set, both of wh...

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Abstract

The invention relates to an application of tumor-derived IgG in diagnosis or prognosis of pancreatic cancer. The invention discloses the application of monoclonal antibodies that specifically recognize a human tumor-derived immune globulin G(CIgG) constant heavy-chain region. The application is characterized by utilizing an immunohistochemical or immunofluorescence technique, determining a pancreatic cancer pathological differentiated degree and patient prognosis according to antibody staining pathological scores, and being used for preparing an immunohistochemistry kit for detecting pancreatic cancer differentiated degree and prognosis evaluation. The application provided by the invention has an important application value for improving the accuracy of pancreatic cancer prognosis evaluation in clinical and scientific research, and provides a basis for individualized diagnosis and treatment scheme of tumor.

Description

Technical field [0001] This application relates to the medical field. Specifically, it involves the field of clinical diagnosis and prognosis. This application relates to the use of tumor-derived IgG as a prognostic marker for pancreatic tumors. Background technique [0002] Pancreatic cancer is still one of the malignant tumors with the highest mortality rate. The incidence of pancreatic cancer is increasing year by year, but its five-year survival rate is still less than 10%. Relevant literature predicts that pancreatic cancer will become the second malignant tumor with tumor-related mortality within 10 years [1-2]. A number of clinicopathological indicators have been used to evaluate the prognosis of pancreatic cancer patients, including tumor pathological grade, lymph node metastasis, CA19-9 level, etc. [3-5]; some molecular markers, such as Ki-67, mTOR pathway molecules, hedgehog Pathway molecules have also been applied to the prognosis of patients with pancreatic cancer....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574G01N33/68
CPCG01N33/57438G01N33/57484G01N33/6854
Inventor 邱晓彦赵玉沛崔铭廖泉由磊黄晶刘乔飞黄歆梅张生华
Owner PEKING UNIV
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