SNP marker related to prognosis of esophageal cancer patients and application thereof

A marker, esophageal cancer technology, applied in the field of SNP markers, can solve the problems of high malignant degree of esophageal cancer, the 5-year survival rate of patients is less than 30%, and no clear and effective molecular targeted drugs have been found, and the results are accurate and reliable. Cleverly designed effects

Inactive Publication Date: 2019-08-30
HUAZHONG UNIV OF SCI & TECH
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  • Abstract
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Problems solved by technology

Moreover, the malignant degree of esophageal cancer is extremely high, and the 5-year survival rate of patients is less than 30%.
Although molecular targeted drugs have been well applied in some solid tumors, at present, no clear and effective molecular targeted drugs have been found in the treatment of esophageal cancer.

Method used

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  • SNP marker related to prognosis of esophageal cancer patients and application thereof
  • SNP marker related to prognosis of esophageal cancer patients and application thereof
  • SNP marker related to prognosis of esophageal cancer patients and application thereof

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Embodiment Construction

[0015] The principles and features of the present invention are described below, and the examples given are only used to explain the present invention, and are not intended to limit the scope of the present invention.

[0016] The technical scheme that the present invention solves the problems of the technologies described above is as follows:

[0017] A SNP marker associated with the prognosis of patients with esophageal cancer, the marker is a combination of rs2274110.

[0018] As for the specific amplification primers of the above SNP markers related to the prognosis of esophageal cancer patients, the sequences of the specific amplification primers for rs2274110 are SEQ ID NO: 1 and SEQ ID NO: 2.

[0019] As for the specific probes of the above SNP markers related to the prognosis of esophageal cancer patients, the probe sequences of rs2274110 are SEQ ID NO: 3 and SEQ ID NO: 4.

[0020] Application of the above SNP markers in the preparation of colorectal cancer auxiliary ...

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Abstract

The invention relates to an SNP marker related to prognosis of esophageal cancer patients and application thereof. The marker is rs2274110. According to the invention, by skillful primer and probe design aiming at the rs2274110 locus, the MCM10 variation detection can be carried out on the esophageal cancer patient by means of fluorescence quantitative PCR, so that high-risk individuals among esophageal cancer patient can be identified, and the judgment on the overall prognosis of the esophageal cancer patients can be assisted. The technical method is ingenious in design, simple and feasible,and accurate and reliable in result, can be popularized in hospitals at all levels, is helpful for evaluating the disease prognosis condition of the esophageal cancer, and is helpful for more active treatment and close follow-up visit on patients with poor prognosis of the esophageal cancer clinically.

Description

technical field [0001] The invention relates to the fields of genetic engineering and tumor medicine, in particular to a SNP marker related to the prognosis of patients with esophageal cancer and its application. Background technique [0002] Esophageal squamous cell carcinoma (esophageal cancer for short) is a common malignant tumor that seriously threatens the health of our people. The mortality rate of esophageal cancer ranks third among malignant tumors in my country. Nearly half of the new cases of esophageal cancer in the world every year are in my country. Moreover, the degree of malignancy of esophageal cancer is extremely high, and the 5-year survival rate of patients is less than 30%. [0003] At present, the treatment of esophageal cancer is mainly surgery, supplemented by radiation therapy and chemotherapy. However, the improvement of overall survival of patients with esophageal cancer by these treatments is still very limited. Although molecular targeted drug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886C12Q2600/118C12Q2600/156
Inventor 缪小平常江钟荣田剑波朱颍
Owner HUAZHONG UNIV OF SCI & TECH
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