Application of loaded sodium calcium phosphosilicate in the preparation of medicaments for the treatment of skin and mucous membrane damage

A sodium calcium phosphosilicate, load-type technology, applied in the field of medicine, can solve the problems of rising above the national standard 8.5, thinning product consistency, substandard products, etc., and achieves the effect of long-term cleansing of the skin and treatment of skin and mucous membrane damage.

Active Publication Date: 2021-09-07
浙江蓝智生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Sodium calcium phosphosilicate, also known as bioactive glass, uses direct powder addition to make water-based cream products, which can easily increase the pH value to above the national standard of 8.5. At the same time, because sodium calcium phosphosilicate contacts with water, it will continue to separate Explain the release of alkalinity. Even if the pH is adjusted to be within 8.5 just after production, it will still cause the problem that the pH value of the finished product will continue to rise to above 9.
On the one hand, this pH rise problem will lead to the thinning of the product consistency, on the other hand, there will be quality problems such as unqualified products.

Method used

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  • Application of loaded sodium calcium phosphosilicate in the preparation of medicaments for the treatment of skin and mucous membrane damage
  • Application of loaded sodium calcium phosphosilicate in the preparation of medicaments for the treatment of skin and mucous membrane damage
  • Application of loaded sodium calcium phosphosilicate in the preparation of medicaments for the treatment of skin and mucous membrane damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] (1) Get sodium calcium phosphosilicate with a particle size of 1 nm to 150 μm, preferably 45S5 and 58S sodium calcium phosphosilicate. Sodium calcium phosphosilicate with particle size within 10 μm is preferred.

[0053] (2) A laser machine is used to irradiate the powder of sodium calcium phosphosilicate with laser to produce nano-micropores with a pore diameter of 1 m-100 μm that can penetrate through sodium calcium phosphosilicate.

[0054] (3) Soak the sodium calcium phosphosilicate with micropores in an aqueous solution simulating artificial sweat for 1-10 days, and filter the soaking solution to obtain modified sodium calcium phosphosilicate powder.

[0055] Wherein, after the aforementioned steps, it includes: adding deionized water to the modified sodium calcium phosphosilicate powder to form a turbid solution, putting the turbid solution into an ultrasonic machine for cleaning 3 times, each time for 1-5 minutes, and filtering again to obtain the after-cleaning ...

Embodiment 2

[0066] (1) Get 1000 g of sodium calcium phosphosilicate with a particle diameter of 150 μm, preferably 45S5 type and 58S type calcium sodium phosphosilicate.

[0067] (2) Microwaves are used to heat the sodium calcium phosphosilicate powder to produce nano-micropores with a pore diameter of 1 nm-100 μm that can penetrate the sodium calcium phosphosilicate.

[0068] (3) Soaking the microporous sodium calcium phosphosilicate into the aqueous solution of simulated artificial sweat for 3-8 days, and filtering the soaking solution to obtain modified sodium calcium phosphosilicate powder.

[0069] Wherein, after the aforementioned steps, it includes: adding deionized water to the modified sodium calcium phosphosilicate powder to form a turbid solution, putting the turbid solution into an ultrasonic machine for cleaning 3 times, each time for 1-20 minutes, and filtering again to obtain the after-cleaning solution. Modified calcium sodium phosphosilicate powder.

[0070] (4) Take 100...

Embodiment 3

[0072] (1) Take 10 μm sodium calcium phosphosilicate, preferably 45S5 type and 58S type sodium calcium phosphosilicate.

[0073] (2) A laser machine is used to irradiate the powder of sodium calcium phosphosilicate with laser light to produce nano-micropores with a pore diameter of 2 μm that can penetrate the sodium calcium phosphosilicate.

[0074] (3) Soak the sodium calcium phosphosilicate with micropores in an aqueous solution simulating artificial sweat for 3-4 days, and filter the soaking solution to obtain modified sodium calcium phosphosilicate powder.

[0075] Wherein, after the aforementioned steps, it includes: adding deionized water to the modified sodium calcium phosphosilicate powder to form a turbid solution, putting the turbid solution into an ultrasonic machine for cleaning 3 times, each time for 1-20 minutes, and filtering again to obtain the after-cleaning solution. Modified calcium sodium phosphosilicate powder.

[0076] (4) Take 100g of modified sodium ca...

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Abstract

The application of a loaded sodium calcium phosphosilicate provided by the invention in the preparation of a drug for treating skin and mucous membrane damage. In the present invention, by designing the microporous structure and slow-release characteristics of sodium calcium phosphosilicate, the functional ingredients (including sodium calcium phosphosilicate) will gradually release their effects, ensuring activity and stable structure to ensure the yield of medicines. ;Several ingredients work together to play a synergistic effect, which can effectively treat skin and mucous membrane damage, anti-inflammatory and degreasing, acne and whitening, long-lasting cleansing of the skin, mild and non-irritating, environmentally friendly and safe.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of loaded sodium calcium phosphosilicate in the preparation of medicines for treating skin and mucous membrane injuries. Background technique [0002] Sodium calcium phosphosilicate, also known as bioactive glass, uses direct powder addition to make water-based cream products, which can easily increase the pH value to above the national standard of 8.5. At the same time, because sodium calcium phosphosilicate contacts with water, it will continue to separate Explain the release of alkalinity. Even if the pH is adjusted to be within 8.5 just after production, it will still cause the problem that the pH value of the finished product will continue to rise to above 9. On the one hand, this pH rise problem leads to thinning of product consistency, and on the other hand, quality problems such as substandard products may occur. How to not only maintain the activity and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61K36/185A61K36/60A61K33/42A61K33/44A61K47/52A61P17/00A61K8/9789A61K8/9794A61K8/24A61K8/19A61Q19/00A61Q19/02
CPCA61K8/19A61K8/24A61K33/42A61K33/44A61K36/185A61K36/60A61K36/899A61K2800/57A61Q19/00A61Q19/02A61K8/9789A61K8/9794A61K47/52A61P17/00A61K2300/00
Inventor 张劲松朱礼飞陈萍毛加萍李保芝易永刚张宇辰
Owner 浙江蓝智生物科技有限公司
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