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3D biological printer spray head capable of detecting cell activity and printing method

A bioprinter and cell activity technology, applied in biochemical equipment and methods, biological material sampling methods, tissue cell/virus culture devices, etc., can solve the problem of low cell survival rate, achieve high recognition rate, reduce The effect of recognition error

Inactive Publication Date: 2019-09-17
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the process of 3D bioprinting, there is often the problem of low survival rate of printed cells. The way to judge the survival rate of cells is to use manual observation after printing. There is no effective way in the process of bioprinting. Accurately monitor cell activity and make judgments for subsequent printing

Method used

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  • 3D biological printer spray head capable of detecting cell activity and printing method
  • 3D biological printer spray head capable of detecting cell activity and printing method
  • 3D biological printer spray head capable of detecting cell activity and printing method

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Embodiment Construction

[0042] The present invention will be further described in detail below in conjunction with specific embodiments, but the protection scope of the present invention is not limited to these embodiments, and all changes or equivalent substitutions that do not depart from the concept of the present invention are included within the protection scope of the present invention.

[0043] A 3D bioprinter nozzle capable of detecting cell activity, comprising a microscopic imaging system 11, a printing system, and a lower computer control core 13 arranged in a fixed housing 4, the microscopic imaging system 11 comprising a microscopic imaging lens 9, a lifting Motor 12, ultrasonic distance measuring sensor 10, described printing system comprises material conveying hose 2, printing nozzle 8, first liquid storage pipe 7, second liquid storage pipe 6 and nozzle support 5, and described fixed housing 4 is provided with nozzle Mounting hole 1, a mechanical fixing piece 3 is set in the middle of ...

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Abstract

The invention discloses a 3D biological printer spray head capable of detecting cell activity and a printing method, which is suitable for different printing models, has controllability, can meet the needs of high-precision biological printing, and can monitor cell activity in the printing process to make a judgment on whether the print is successful or not. The invention is realized by the following technical schemes: the 3D biological printer spray head capable of detecting cell activity includes a microscopic imaging system, a printing system and a slave computer control core which are arranged in a fixed housing, and the slave computer control core controls the microscopic imaging system to take pictures, store pictures and transmit pictures to a master computer at the same time; and the printing method using the 3D biological printer spray head includes two printing modes: a normal printing mode and a microscopic imaging mode.

Description

technical field [0001] The invention discloses a 3D bioprinter nozzle capable of detecting cell activity and a printing method, belonging to the technical field of 3D bioprinting equipment. Background technique [0002] 3D bioprinting is a technology that incrementally assembles biomaterials including gel, chitosan, cell unit, agarose, etc. into a specified structure driven by a three-dimensional digital model, and solidifies it. The printed biomaterials or cell building blocks can be cultivated to produce real living tissues, which can be used for organ transplantation, tissue engineering scaffolds, skin regeneration, etc., and have strong vitality and broad industrial prospects. [0003] 3D bioprinters can be divided into inkjet printing, extrusion bioprinting, laser-assisted bioprinting, etc. Extrusion bioprinting usually uses dispensing needles for discharge, and the dispensing needles are needle-shaped or conical. Laser-assisted printing can significantly reduce the ra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/00B33Y30/00
CPCC12M33/00B33Y30/00
Inventor 桑胜波张成然张博周传刚袁仲云禚凯程永强孙建其
Owner TAIYUAN UNIV OF TECH
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