A nanoemulsion gel eye drop for treating keratitis and preparation method thereof

A technology of nanoemulsion and eye drops, applied in the field of medicine and medicine, can solve the problems of low solubility of triptolide alcohol and the like

Active Publication Date: 2021-07-06
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention discloses a nanoemulsion gel eye drop for treating keratitis. By making the nanoemulsion gel eye drop, the problem of low solubility of triptolide is solved, the toxicity of triptolide is reduced, and the efficacy of the drug is improved. Corneal permeability and prolonged ocular residence time of the drug

Method used

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  • A nanoemulsion gel eye drop for treating keratitis and preparation method thereof
  • A nanoemulsion gel eye drop for treating keratitis and preparation method thereof
  • A nanoemulsion gel eye drop for treating keratitis and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] A kind of triptolide nanoemulsion gel eye drops, calculated according to the total mass percentage of raw materials:

[0034] Triptolide 0.1 part;

[0035] Polyoxyethylene castor oil EL 13.5 parts;

[0036] Caprylic capric acid macrogol glyceride 4.5 parts;

[0037] 2 parts of oleoyl polyoxyethylene glyceride;

[0038] Poloxamer 407 22.5 parts;

[0039] Poloxamer 188 3.2 parts;

[0040] The balance of water for injection.

[0041] Preparation:

[0042] 1) Dissolve triptolide in the oil phase, and magnetically stir the rotor at 1000-2000rpm for 10-30min;

[0043] 2) Add surfactant, and magnetically stir the rotor at 1000-2000rpm for 10-30min;

[0044] 3) Add co-surfactant, and magnetically stir the rotor at 1000-2000rpm for 10-30min;

[0045] 4) Then add deionized water drop by drop while magnetically stirring, and magnetically stir for 12-24h with the rotor at 1000-2000rpm to make nanoemulsion;

[0046] 5) Add the temperature-sensitive gel matrix in an ice bath...

Embodiment 2

[0049] A kind of triptolide nanoemulsion gel eye drops, calculated according to the total mass percentage of raw materials:

[0050] Triptolide 0.1 part;

[0051] Polyoxyethylene castor oil EL 16.3 parts;

[0052] Caprylic capric acid macrogol glyceride 3.7 parts;

[0053] 7.5 parts of oleoyl polyoxyethylene glyceride;

[0054] Poloxamer 407 22.5 parts;

[0055]Poloxamer 188 3.2 parts;

[0056] The balance of water for injection.

[0057] The preparation method is the same as that of Example 1, and the particle diameter of Example 2 measured in a laser particle size analyzer is 18.7nm.

Embodiment 3

[0059] A kind of triptolide nanoemulsion gel eye drops, calculated according to the total mass percentage of raw materials:

[0060] Triptolide 0.1 part;

[0061] Polyoxyethylene castor oil EL 16.3 parts;

[0062] Caprylic capric acid macrogol glyceride 3.7 parts;

[0063] 11.5 parts of oleoyl polyoxyethylene glyceride;

[0064] Poloxamer 407 22.5 parts;

[0065] Poloxamer 188 3.2 parts;

[0066] The balance of water for injection.

[0067] The preparation method is the same as that of Example 1, and the particle diameter of Example 3 measured in a laser particle size analyzer is 14.1 nm.

[0068] The particle size distribution figure of the triptolide nanoemulsion gel: get the triptolide nanoemulsion gel prepared under the conditions of Example 1 and measure the particle size distribution by laser particle size analyzer, the results are shown in figure 1 , The average particle size is 20.2nm.

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Abstract

The invention discloses a nanoemulsion gel eye drop for treating keratitis and a preparation method thereof, by preparing an ophthalmic triptolide nanoemulsion gel drug delivery system, and researching the anti-inflammatory effect and mechanism of the dosage form; Using the solubilization characteristics of nanoemulsions, the solubility of the insoluble drug triptolide was improved, and the antibacterial effect of triptolide nanoemulsions was studied; the use of temperature-sensitive in situ gels can prolong the drug action time. Features, make triptolide can achieve the effect of sustained release in the eyes, thereby exerting the anti-inflammatory effect of the drug, and at the same time play the effect of attenuating; The anti-inflammatory effect and molecular mechanism of alcohol nanoemulsion gel were studied in animals.

Description

technical field [0001] The invention discloses a nanoemulsion gel eye drop for treating keratitis and a preparation method thereof, which is an ophthalmic preparation having good anti-inflammatory effects both on exogenous infection and endogenous infection, and belongs to the technical field of medicine and medicine. Background technique [0002] Infectious inflammation of the eye is a disease caused by some exogenous inflammatory factors, such as conjunctivitis and keratitis caused by bacteria and viruses, and is generally treated with antibacterial or antiviral eye drops; Non-infectious ocular inflammation is caused by non-infectious etiology, such as dry eye syndrome, uveitis and other diseases caused by immune and metabolic diseases, which are generally treated with hormones and immunosuppressant drugs for treatment. Infectious keratitis is an eye disease caused by bacteria, fungi, and viruses that scars the cornea, develops new blood vessels, and can eventually lead t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K47/10A61K47/44A61K47/14A61K31/585A61P27/02A61P31/00
CPCA61K9/0048A61K9/06A61K31/585A61K47/10A61K47/14A61K47/44A61P27/02A61P31/00
Inventor 张桂荣邓鹏张冰洁张雪妍绍恩泽
Owner JILIN UNIV
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