Inhibition of platelet aggregation using Anti-human gpvi antibodies

A technology of antibody molecules and uses, which is applied in the field of cardiovascular disease treatment and can solve problems such as being uncontrollable
CN110494447APending Publication Date: 2019-11-22ACTICOR BIOTECH +4
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ACTICOR BIOTECH
Publication Date
2019-11-22

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Abstract

The present invention relates to an isolated humanized protein binding to human Glycoprotein VI (hGPVI ) for treating a GPVI-related condition in a subject in need thereof, wherein said isolated humanized protein is to be administered during at least 2 hours to the subject, preferably during at least 4 to 6 hours.
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Description

[0001] field of invention

[0002] The present invention relates to the treatment of cardiovascular diseases. In particular, the invention relates to methods of treating cardiovascular disease comprising the continuous administration of novel anti-human glycoprotein VI antibodies or fragments thereof to human patients in need thereof.

[0003] Background of the invention

[0004] Acute coronary and cerebrovascular events are currently the leading causes of death in the world. Furthermore, the global incidence of relapse and death in the post-treatment 6-month cycle after acute coronary syndrome remains 8-15%.

[0005] In the case of acute coronary syndrome with ST-segment elevation, mechanical treatment with coronary angioplasty and introduction of a stent is highly effective for urgent restoration of coronary blood flow, but does not prevent the subsequent 6-month Morbidity / mortality in approximately 15% of patients. Thrombolytic therapy based on a combination of long-term ...

Claims

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