Application of tyrosine kinase inhibitor as treatment drug for acute kidney injury
A technology for acute kidney injury and tyrosine kinase, which can be used in drug combinations, pharmaceutical formulations, organic active ingredients, etc., to solve problems such as unclear regulatory mechanisms and elevated levels of PDCD4 expression in the kidneys
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[0108] 1. Experimental steps
[0109] 1. Expression distribution and role of PDCD4 in renal ischemia-reperfusion injury
[0110] 1.1 The expression changes and role of PDCD4 in ischemia-reperfusion injury
[0111] 1.1.1 Establish a mouse model of renal ischemia-reperfusion injury and detect the expression changes of PDCD4
[0112] 12-week-old C57BL / 6J male mice were selected to establish an acute renal ischemia-reperfusion model, and real-time fluorescent quantitative PCR (Real-time RT-PCR), WB, and immunohistochemical staining (Immunohistochemical–staining, IHC) were used to detect PDCD4 in The expression changes of mRNA and protein levels at different time points after ischemia-reperfusion, namely 24h, 48h, and 72h. At the same time, the expression distribution of PDCD4 in the proximal convoluted tubule, distal convoluted tubule and collecting duct of the kidney and the expression change of renal ischemia-reperfusion injury were detected by immunofluorescence (Immunofluore...
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