Application of tyrosine kinase inhibitor as treatment drug for acute kidney injury

A technology for acute kidney injury and tyrosine kinase, which can be used in drug combinations, pharmaceutical formulations, organic active ingredients, etc., to solve problems such as unclear regulatory mechanisms and elevated levels of PDCD4 expression in the kidneys
CN110538181AActive Publication Date: 2019-12-06SHANDONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG UNIV
Publication Date
2019-12-06

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Abstract

The invention belongs to the technical field of kidney injury treatment drugs, and particularly relates to application of ponatinib as a drug for acute kidney injury. As an acute clinical complication, the acute kidney injury has the characteristics of being high in morbidity and high in mortality, and effective treatment drugs are not achieved at present. Related researchers in the field show that PDCD4 expression becomes higher in an acute kidney injury model, and it is indicated that the PDCD4 plays an important role in the physiological mechanism related to the acute kidney injury. The situation that the PDCD4 aggravates the kidney injury by regulating an Fgr-Stat3-Notch1 pathway is further confirmed. The confirmation of the regulatory mechanism provides a basis for the treatment of the acute kidney injury. According to the research results, the ponatinib, an Fgr kinase inhibitor, is adopted to treat the acute kidney injury, the drug has a significant protective effect on the injury caused by kidney ischemia reperfusion, and it is indicated that the drug intervention in Fgr can prevent and treat the acute kidney injury.
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Description

technical field

[0001] The disclosure belongs to the technical field of drugs for treating acute kidney injury, and in particular relates to the application of tyrosine kinase inhibitors as drugs for acute kidney injury. Background technique

[0002] The information disclosed in this Background section is only intended to increase the understanding of the general background of the disclosure, and is not necessarily to be taken as an acknowledgment or any form of suggestion that the information constitutes prior art that is already known to those skilled in the art.

[0003] Acute Kidney Injury (AKI) is a serious clinical complication with rapid onset and rapid progress, and it is also an important cause of chronic renal failure. In severe cases, it can develop into systemic complications such as uremia, and has high Characterized by morbidity and high mortality. Clinically, it is usually caused by ischemia / reperfusion injury (IRI), sepsis or chemotherapy drugs, etc. Althoug...

Claims

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