Application of tyrosine kinase inhibitor in preparation of medicine for treating acute kidney injury

A technology for acute kidney injury and kidney injury, applied in drug combinations, pharmaceutical formulations, organic active ingredients, etc., can solve problems such as unclear regulatory mechanism and increased expression of PDCD4 in the kidney
CN110538181BActive Publication Date: 2020-06-16SHANDONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANDONG UNIV
Publication Date
2020-06-16

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Abstract

An application of Ponatinib as a drug for acute kidney injury. Since PDCD4 aggravates the kidney injury by regulating an Fgr-Stat3-Notch1 pathway, the ponatinib, an Fgr kinase inhibitor, is adopted to treat the acute kidney injury. The drug has a significant protective effect on the injury caused by kidney ischemia reperfusion, and it is indicated that the drug intervention in Fgr can prevent and treat the acute kidney injury.
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Description

technical field

[0001] The disclosure belongs to the technical field of drugs for treating acute kidney injury, and in particular relates to the application of tyrosine kinase inhibitors as drugs for acute kidney injury. Background technique

[0002] The information disclosed in this Background section is only intended to increase the understanding of the general background of the disclosure, and is not necessarily to be taken as an acknowledgment or any form of suggestion that the information constitutes prior art that is already known to those skilled in the art.

[0003] Acute Kidney Injury (AKI) is a serious clinical complication with rapid onset and rapid progress, and it is also an important cause of chronic renal failure. In severe cases, it can develop into systemic complications such as uremia, and has high Characterized by morbidity and high mortality. Clinically, it is usually caused by ischemia / reperfusion injury (IRI), sepsis or chemotherapy drugs, etc. Althoug...

Claims

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