Application of hypotensor Pempidine serving as novel antiarrhythmic drug

Abstract

The invention discloses application of Pempidine in the preparation of drugs for treating arrhythmia. The invention discovers that Pempidine can be effectively used as an IK1 specific agonist, has a similar effect as zacopride and can be used for preparing antiarrhythmic drugs for the first time, and accordingly a novel approach which is effective and capable of achieving safety treatment is provided.

Description

technical field [0001] The invention relates to a cardiovascular disease drug, in particular to the application of Panbis in the preparation of drugs for treating arrhythmia. Background technique [0002] Arrhythmia refers to the abnormality of heartbeat frequency and rhythm, and severe arrhythmia is often one of the main causes of death in patients with cardiovascular diseases. The mechanism of severe arrhythmia is very complicated, and it is often not a single mechanism, but at its root, there are changes in the functional activities of myocardial ion channels, and the changes in ion currents caused by this will affect the occurrence and shape of action potentials. Those drugs that alter the action potential may thus have a proarrhythmic risk or an antiarrhythmic effect. [0003] At present, almost all antiarrhythmic drugs in clinical use are various ion channel blockers, and their main targets act on Na . Kv , Ca ion channels. Disorder drugs fall into four categories: ...

AI Technical Summary

Problems solved by technology

The mechanism of severe arrhythmia is very complicated, and it is often not a single mechanism, but at its root, there are changes in the functional activities of myocardial ion channels, and the changes in ion currents caused by this will affect the occurrence and shape of action potentials

Drugs that alter action potentials and thus may have proarrhythmic risk or antiarrhythmic effects

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