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Preparation method of curcumin/piperine solid dispersion

A technology of solid dispersion and piperine, applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve problems such as limiting clinical applications, and achieve easy operation and considerable clinical application value , Improve the solubility and the effect of in vitro dissolution

Inactive Publication Date: 2020-04-28
HAIMEN YUANMEI MEISHU TUAN SHEJI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, both curcumin and piperine are water-insoluble drugs, and their solubility in water is 7.8 and 22.34 μg / ml respectively, which limits their clinical application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] A preparation method of curcumin / piperine solid dispersion, comprising the steps of: mixing 15 parts of curcumin, 8 parts of piperine and 60 parts of carrier PVP K30, adding absolute ethanol to dissolve, and rotating under reduced pressure at 45°C Remove the solvent by evaporation, vacuum-dry at 50°C, grind, and pass through an 80-mesh sieve to obtain the product; all raw materials are in parts by weight.

Embodiment 2

[0014] A preparation method of curcumin / piperine solid dispersion, comprising the steps of: mixing 10 parts of curcumin, 7 parts of piperine and 55 parts of carrier PVP K30, adding absolute ethanol to dissolve, and rotating under reduced pressure at 40°C Remove the solvent by evaporation, vacuum-dry at 45°C, grind, and pass through an 80-mesh sieve to obtain the product; all raw materials are in parts by weight.

Embodiment 3

[0016] A preparation method of curcumin / piperine solid dispersion, comprising the steps of: mixing 20 parts of curcumin, 9 parts of piperine and 65 parts of carrier PVP K30, adding absolute ethanol to dissolve, and rotating under reduced pressure at 50°C Remove the solvent by evaporation, vacuum-dry at 55°C, grind, and pass through an 80-mesh sieve to obtain the product; all raw materials are in parts by weight.

[0017] The method is simple, quick and easy to operate, effectively improves the solubility and in vitro dissolution rate of poorly soluble drugs, and has considerable clinical application value. design basis.

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Abstract

The invention discloses a preparation method of a curcumin / piperine solid dispersion. The preparation method comprises the following steps: uniformly mixing, by weight, 10-20 parts of curcumin, 7-9 parts of piperine and 55-65 parts of a carrier PVP K30, adding anhydrous ethanol to dissolve, carrying out rotary evaporation under a reduced pressure at 40-50 DEG C to remove a solvent, carrying out vacuum drying at 45-55 DEG C, grinding, and sieving with an 80-mesh sieve to obtain the curcumin / piperine solid dispersion. The method is simple, quick and easy to operate, effectively improves the solubility and in-vitro dissolution rate of insoluble drugs, has considerable clinical application values, and provides a basis for the design of the preparation of curcumin and piperine combined oral administration preparations with physicochemical characteristics and pharmacological relationship.

Description

technical field [0001] The invention relates to a preparation method of curcumin / piperine solid dispersion. Background technique [0002] Curcumin (curcumin) is derived from zingiberaceae ( Curcumin longa The polyphenols extracted from L.) have a wide range of pharmacological effects, such as anti-inflammatory, anti-oxidation, anti-depression, anti-cancer, and liver protection. It is often used in combination with piperine, which can synergistically improve the increase of inflammatory factor TNF-α and apoptosis factor caspase-3, which leads to the decrease of brain neurogenesis factors, leading to depression symptoms, and enhances its antidepressant effect; significantly improves the antidepressant effect on ulcerative colitis and antitumor In addition, the combined application also has the effects of reducing DNA damage and neurotoxicity, and enhancing immunity. The common compatibility ratio is between 1:1 and 1:400. However, both curcumin and piperine are insoluble in...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/4525A61K31/12A61K47/32A61P25/24
CPCA61K9/146A61K31/12A61K31/4525A61P25/24A61K2300/00
Inventor 不公告发明人
Owner HAIMEN YUANMEI MEISHU TUAN SHEJI CO LTD
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