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Gastric floating tablet and preparation method thereof

A gastric floating tablet and tablet compression technology, which is applied in the field of medicine, can solve the problems of increasing the burden of digestion and degradation of the body, and achieve the effects of reducing the burden on the stomach and damage to the body, prolonging the floating time, and simple preparation methods

Active Publication Date: 2021-06-08
SHANGHAI JIAOTONG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this patent relies on high-concentration and low-density polymer materials to obtain the floating effect, which will increase the burden of digestion and degradation of the body

Method used

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  • Gastric floating tablet and preparation method thereof
  • Gastric floating tablet and preparation method thereof
  • Gastric floating tablet and preparation method thereof

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preparation example Construction

[0048] The present invention also provides a preparation method for the above-mentioned gastric floating tablet, comprising the following steps:

[0049] Grinding the porogen and passing through a mesh sieve;

[0050] Mix excipients, drugs, lubricants and porogens evenly, and compress into tablets;

[0051] Place the compressed tablet in a vacuum oven at 50-80°C for 12h-36h to obtain a gastric floating tablet.

[0052] In one embodiment, the mesh size is 200 μm-500 μm.

[0053] In one of the embodiments, the compression condition of the tablet is: a compression strength of 70kg / cm 2 ~90kg / cm 2 , compression time 1s ~ 10s.

Embodiment 1

[0055] Example 1 (F1)

[0056] At room temperature, grind 50mg of L-menthol and pass through a 300-mesh sieve;

[0057] Mix 200mg zein, 50mg captopril, 3mg magnesium stearate and L-menthol, pass through a 300-mesh sieve, 80kg / cm 2 Press the tablet under pressure for 2s;

[0058] Place the compressed tablet in a vacuum oven at 60°C for 24 hours to obtain a gastric floating tablet.

Embodiment 2

[0059] Example 2 (F2)

[0060] At room temperature, grind 75mg of L-menthol and pass through a 300-mesh sieve;

[0061] Mix 200mg zein, 50mg captopril, 3.25mg magnesium stearate and L-menthol, pass through a 300-mesh sieve, 80kg / cm 2 Press the tablet under pressure for 2s;

[0062] Place the compressed tablet in a vacuum oven at 70°C for 12 hours to obtain a gastric floating tablet.

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Abstract

The invention relates to a gastric floating tablet and a preparation method thereof. The gastric floating tablet comprises the following components in mass percentage: 25%-89.5% of excipients, 5%-30% of drugs, 0.5%-5% of lubricants and Pore ​​agent 5% to 40%. Compared with the prior art, the main component of the gastric floating tablet of the present invention is food protein, and no additional foaming agent or other components to control drug release are added, which reduces the stomach burden and body damage caused by complex external components; the prepared The porous floating sheet has no floating hysteresis, which prolongs the floating time of the floating sheet in the stomach; and maintains good mechanical stability in the digestive juice for a long time; it acts as a barrier by forming a gel-like layer when it contacts with the medium at 37°C Stasis agent, so that the loaded drug can be released continuously, and the drug effect is obvious. The simple components realize multiple functions, and the preparation method of direct compression is simple, which greatly reduces the preparation cost.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a gastric floating tablet and a preparation method thereof. Background technique [0002] In the existing medical field, many drugs have the disadvantages of poor solubility, easy loss of stability in gastric juice, or being metabolized by gastrointestinal fluid to lose their due efficacy. Although increasing the drug dose can improve the therapeutic effect, it will bring harm to the body. To increase the burden of drug toxicity, increasing the dosage will also increase the drug resistance of the body, so the development of intragastric drug retention carrier system has become an effective treatment. [0003] In the traditional technology, there are mucoadhesive carrier systems, magnetically controlled drug carrier systems, swelling carrier systems, etc. to increase the release time of drugs in the stomach, but all of them need to add additional ingredients to assist the complet...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K31/401A61K47/38A61K47/42A61K47/36A61K47/26A61K47/10A61P9/12A61P9/04
CPCA61K9/0065A61K9/2013A61K9/2018A61K9/205A61K9/2054A61K9/2063A61K9/2095A61K31/401A61P9/04A61P9/12
Inventor 王瑾晔阿里·拉扎
Owner SHANGHAI JIAOTONG UNIV
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