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Stomach floating tablet and preparation method thereof

A gastric floating tablet and tablet pressing technology, applied in the field of medicine, can solve problems such as increasing the burden of digestion and degradation of the body, and achieve the effects of reducing the burden on the stomach and body damage, prolonging the floating time, and having obvious medicinal effect.

Active Publication Date: 2020-06-05
SHANGHAI JIAO TONG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this patent relies on high-concentration and low-density polymer materials to obtain the floating effect, which will increase the burden of digestion and degradation of the body

Method used

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  • Stomach floating tablet and preparation method thereof
  • Stomach floating tablet and preparation method thereof
  • Stomach floating tablet and preparation method thereof

Examples

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preparation example Construction

[0048] The present invention also provides a preparation method for the above-mentioned gastric floating tablet, comprising the following steps:

[0049] Grinding the porogen and passing through a mesh sieve;

[0050] Mix excipients, drugs, lubricants and porogens evenly, and compress into tablets;

[0051] Place the compressed tablet in a vacuum oven at 50-80°C for 12h-36h to obtain a gastric floating tablet.

[0052] In one embodiment, the mesh size is 200 μm-500 μm.

[0053] In one of the embodiments, the compression condition of the tablet is: a compression strength of 70kg / cm 2 ~90kg / cm 2 , compression time 1s ~ 10s.

Embodiment 1

[0055] Example 1 (F1)

[0056] At room temperature, grind 50mg of L-menthol and pass through a 300-mesh sieve;

[0057] Mix 200mg zein, 50mg captopril, 3mg magnesium stearate and L-menthol, pass through a 300-mesh sieve, 80kg / cm 2 Press the tablet under pressure for 2s;

[0058] Place the compressed tablet in a vacuum oven at 60°C for 24 hours to obtain a gastric floating tablet.

Embodiment 2

[0059] Example 2 (F2)

[0060] At room temperature, grind 75mg of L-menthol and pass through a 300-mesh sieve;

[0061] Mix 200mg zein, 50mg captopril, 3.25mg magnesium stearate and L-menthol, pass through a 300-mesh sieve, 80kg / cm 2 Press the tablet under pressure for 2s;

[0062] Place the compressed tablet in a vacuum oven at 70°C for 12 hours to obtain a gastric floating tablet.

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Abstract

The invention relates to a stomach floating tablet and a preparation method thereof. The stomach floating tablet is prepared from the the following components in percentage by mass: 25%-89.5% of an excipient, 5%-30% of a medicine, 0.5%- 5% of a lubricant and 5%-40% of a pore-forming agent. Compared with the prior art, the main component of the gastric floating tablet is food protein, and no additional foaming agent or other components for controlling the release of medicines are added, and the stomach burden and body damage caused by complex external addition components are reduced; the prepared porous floating tablet has no floating lag time, and the floating time of the floating tablet in the stomach is prolonged; good mechanical stability in digestive juice is maintained for a long time; the stomach floating tablet acts as a retarding agent by forming a gel layer when in contact with a medium at 37 DEG C, so that the loaded medicines can be continuously released, and the medicine effect is obvious; and multiple functions are realized through the simple components, and the preparation method of the direct tablet compression is simple, so that the preparation cost is greatly reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a gastric floating tablet and a preparation method thereof. Background technique [0002] In the existing medical field, many drugs have the disadvantages of poor solubility, easy loss of stability in gastric juice, or being metabolized by gastrointestinal fluid to lose their due efficacy. Although increasing the drug dose can improve the therapeutic effect, it will bring harm to the body. To increase the burden of drug toxicity, increasing the dosage will also increase the drug resistance of the body, so the development of intragastric drug retention carrier system has become an effective treatment. [0003] In the traditional technology, there are mucoadhesive carrier systems, magnetically controlled drug carrier systems, swelling carrier systems, etc. to increase the release time of drugs in the stomach, but all of them need to add additional ingredients to assist the complet...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/401A61K47/38A61K47/42A61K47/36A61K47/26A61K47/10A61P9/12A61P9/04
CPCA61K9/0065A61K9/2013A61K9/2018A61K9/205A61K9/2054A61K9/2063A61K9/2095A61K31/401A61P9/04A61P9/12
Inventor 王瑾晔阿里·拉扎
Owner SHANGHAI JIAO TONG UNIV
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