CeRNA competition model identification method and device, electronic equipment and storage medium

An identification method, RNA2-RNA2 technology, applied in electronic equipment and storage media, ceRNA competition module identification method, device field, can solve the problem of not being able to identify ceRNA internal competition modules, etc.

Active Publication Date: 2020-07-07
UNIV OF ELECTRONICS SCI & TECH OF CHINA +1
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Problems solved by technology

[0005] The object of the present invention is to, aiming at the deficiencies in the above-mentioned prior art, provide a kind of ceRNA competition module recognition ...

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  • CeRNA competition model identification method and device, electronic equipment and storage medium
  • CeRNA competition model identification method and device, electronic equipment and storage medium
  • CeRNA competition model identification method and device, electronic equipment and storage medium

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Embodiment Construction

[0027]In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments It is a part of embodiments of the present invention, but not all embodiments.

[0028] figure 1 It is a schematic flowchart of a method for identifying a ceRNA competition module provided in an embodiment of the present application. The subject of execution of the method is an electronic device with data processing capabilities, such as a notebook computer, a desktop computer, a mobile terminal, a server, a cloud server, etc., and there is no limitation here.

[0029] Such as figure 1 As shown, the ceRNA competition module identification method includes:

[0030] S11, according to RNA respectively 1 expression matrix and RNA...

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Abstract

The invention provides a ceRNA competition model identification method and device, electronic equipment and a storage medium, and relates to the field of gene identification. The ceRNA competition model identification method comprises the steps of obtaining an RNA1 gene module and an RNA2 gene module according to the expression matrix of the RNA1 and the expression matrix of the RNA2, wherein theRNA1 and the RNA2 are miRNA target genes; regulating relation data, a miRNA expression matrix, an RNA1 gene module and an RNA2 gene module according to the prior miRNA-target gene, and performing identification for obtaining the ceRNA competition module which satisfies a condition, wherein the ceRNA competition module comprises an inner competition module and an outer competition module. Because the inner and outer competition conditions of the ceRNA are considered, the inner and outer competition strength of the ceRNA and the influence of the miRNA to the inner and outer competition strengthsof the ceRNA are measured in a module level. Therefore, the method provided by the invention can accurately identify the ceRNA competition module.

Description

technical field [0001] The invention relates to the technical field of gene identification, in particular to a method, device, electronic equipment and storage medium for identifying a ceRNA competition module. Background technique [0002] Micro Ribonucleic Acid (miRNA) is a kind of non-coding small ribonucleic acid (Ribonucleic Acid, RNA) molecule. miRNA mainly affects the expression level of target genes by negatively regulating target genes. However, according to the endogenous competing RNA (competing endogenous RNA, ceRNA) hypothesis, target genes that share miRNA response elements (miRNA response elements, MREs) can also compete with each other to affect their respective gene expression levels. These target genes (including coding genes and non-coding genes) that share the same MREs and form a competitive relationship are collectively referred to as ceRNA or miRNA sponges. [0003] In the prior art, the application scheme with application number CN201910684738.7 pro...

Claims

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Application Information

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IPC IPC(8): G16B20/00G06K9/62
CPCG16B20/00G06F18/23
Inventor 张俊鹏饶妮妮王光斌
Owner UNIV OF ELECTRONICS SCI & TECH OF CHINA
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