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Pharmaceutical composition for treating interstitial lung disease

A composition and interstitial technology, which can be used in drug combinations, pharmaceutical formulations, plant raw materials, etc., can solve problems such as the complex mechanism of interstitial lung disease, and achieve the effects of simple formulation, improved respiratory function, and improved quality of life.

Active Publication Date: 2020-08-07
北京东方运嘉科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, there are many types of interstitial lung diseases and their mechanisms are complex. The exploration of the

Method used

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  • Pharmaceutical composition for treating interstitial lung disease
  • Pharmaceutical composition for treating interstitial lung disease
  • Pharmaceutical composition for treating interstitial lung disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Take 15g of astragalus, 15g of raw licorice, 10g of earthworm, 8g of wild chrysanthemum and 3g of Trichosanthes, add 10 times the amount of distilled water, soak for 30 minutes, decoct until the remaining half of the water, pour out the liquid medicine, and then add 10 times the amount of distilled water, Boil until half of the water remains, pour out the medicinal liquid, and mix with the previous medicinal liquid to obtain a decoction.

Embodiment 2

[0037] Take 1500g of Astragalus membranaceus, 1500g of raw licorice, 800g of wild chrysanthemum, and 300g of Trichosanthes, add 5 times the amount of 75% ethanol to reflux and extract twice, each time for 2 hours, filter, and combine the filtrates to obtain filtrate 1, and the medicinal residues are set aside; Take 1000g of earthworm, add 5 times the amount of 0.9% sodium chloride solution to extract 2 times, each time for 2 hours, filter, combine the filtrates to obtain filtrate 2, and use the dregs for later use; take all the dregs obtained above, combine them and use them Decoct and extract twice with 3 times the amount of water, filter the extract to obtain filtrate 3; combine filtrates 1-3, concentrate under reduced pressure to a thick paste with a relative density of 1.15-1.25, and further dry under reduced pressure to obtain a dry paste, according to conventional methods The dry paste is prepared as granules.

Embodiment 3

[0039]Take 1300g of Astragalus membranaceus, 1300g of raw licorice, 800g of wild chrysanthemum, and 300g of Trichosanthes, add 3 times the amount of 80% ethanol to reflux and extract 3 times, each time for 2 hours, filter, and combine the filtrates to obtain filtrate 1, and the dregs of the medicine are set aside; Take 900 g of earthworm, add 5 times the amount of 0.9% sodium chloride solution to extract twice, each time for 2 hours, filter, combine the filtrates to obtain filtrate 2, and use the dregs for later use; Decoct and extract 3 times with 3 times the amount of water, filter the extract to obtain filtrate 3; combine filtrates 1-3, concentrate under reduced pressure to a thick paste with a relative density of 1.15-1.25, and further dry under reduced pressure to obtain a dry paste, according to conventional methods The dry paste is prepared as tablets.

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Abstract

The invention relates to a pharmaceutical composition for treating interstitial lung disease and a preparation method thereof. The composition is prepared from 10-15 parts of astragalus membranaceus,10-15 parts of raw liquorice roots, 6-10 parts of earthworms, 5-8 parts of wild chrysanthemum flowers and 1-5 parts of trichosanthes kirilowii. The pharmaceutical composition is simple in formula, beneficial to product quality control and production cost reduction, capable of relieving a cough, reducing sputum, effectively improving the respiratory function of a patient, improving the life qualityof the patient and delaying disease progression, and free of obvious side effects.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, more specifically, a pharmaceutical composition for treating interstitial lung disease. Background technique [0002] Interstitial lung disease, also known as pulmonary interstitial disease, diffuse parenchymal lung disease or invasive lung disease, consists of a large group of heterogeneous lung diseases, including two categories of known and unknown causes. The known causes mainly include pneumoconiosis caused by occupational environment, exogenous hypersensitivity pneumonitis, etc., or induced by drugs. Unknown causes include idiopathic pulmonary interstitial fibrosis, pulmonary hemorrhage nephritic syndrome, and sarcoidosis. Clinical manifestations are usually progressive dyspnea, dry cough, wheezing, etc. Chest X-rays show diffuse reticular, nodular or fine nodular infiltrative shadows in both lungs, and histological features show non-neoplastic inflammatory changes Or with infl...

Claims

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Application Information

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IPC IPC(8): A61K36/484A61P11/00A61P11/14A61P11/10A61K35/62
CPCA61K36/481A61K36/484A61K35/62A61K36/287A61K36/428A61P11/00A61P11/14A61P11/10A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 晁燕
Owner 北京东方运嘉科技发展有限公司