Oral solid self-emulsifying dispersoid for treating respiratory diseases of livestock and poultry

A self-emulsifying, respiratory technology, which is applied in the direction of respiratory diseases, climate change adaptation, medical preparations of non-active ingredients, etc., can solve problems such as residues, drug-resistant strains of drugs, poor treatment effect, etc., and achieve improved stability , improve efficacy and prolong storage time

Active Publication Date: 2018-04-20
XINYANG AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide an oral solid self-emulsifying dispersion for the treatment of livestock and poultry respiratory diseases, which can effectively solve the problems of poor therapeutic effect and easy to produce drug-resistant strains and drug residues

Method used

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  • Oral solid self-emulsifying dispersoid for treating respiratory diseases of livestock and poultry
  • Oral solid self-emulsifying dispersoid for treating respiratory diseases of livestock and poultry
  • Oral solid self-emulsifying dispersoid for treating respiratory diseases of livestock and poultry

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 preparation volatile oil

[0022] 1. Mix forsythia oil, eucalyptus oil, almond oil, bellflower oil, and perilla oil in a ratio of 2:5:1:1:1 by weight to prepare 1# volatile oil;

[0023] 2. Mix forsythia oil, eucalyptus oil, almond oil, bellflower oil, and perilla oil in a ratio of 4:3:2:2:1 by weight to prepare 2# volatile oil;

[0024] 3. Mix forsythia oil, eucalyptus oil, almond oil, bellflower oil, and perilla oil in a ratio of 5:2:3:3:0.5 by weight to prepare 3# volatile oil.

Embodiment 2

[0025] Example 2 Preparation of oral solid self-emulsifying dispersion for the treatment of livestock and poultry respiratory diseases

[0026] The first step is to accurately weigh 60g of 1# volatile oil, 30g of emulsifier, 10g of co-emulsifier, and 200g of solid dispersant carrier according to parts by weight; first, add emulsifier and co-emulsifier to 1# volatile oil. Stir to mix;

[0027] In the second step, after melting the solid dispersant carrier in a water bath at 80°C, slowly add the material stirred and mixed in the first step while continuously stirring, and form a volatile oil self-emulsifying mixture after mixing evenly;

[0028] In the third step, pour the volatile oil self-emulsifying mixture obtained in the second step onto a glass plate pre-cooled to 4°C to cool and solidify, then freeze at -18°C for 2 hours, and finally crush it through an 80-mesh sieve to obtain 1# Oral solid self-emulsifying dispersion product containing volatile oil.

[0029] By the sam...

Embodiment 3

[0032] Example 3 Quality Evaluation of Oral Solid Self-emulsifying Dispersion Finished Products Prepared by the Present Invention

[0033] 1. Shape

[0034] The finished products of 1#, 2#, 3# oral solid self-emulsifying dispersion prepared by the present invention are white or light yellow powder with the smell of essential oil.

[0035] 2. Self-emulsification rate

[0036] The rate of self-emulsification is an important parameter for evaluating solid self-emulsifying dispersions. The self-emulsification rates of 1#, 2#, and 3# oral solid self-emulsifying dispersions containing volatile oil in water and PBS with pH 7.4 were inspected by visual inspection, and the results are shown in Table 1 below.

[0037] Table 1

[0038]

[0039] Conclusion: From the results in Table 1 above, it can be seen that the self-emulsification rate of the oral solid self-emulsifying dispersion prepared by the present invention is relatively fast, and meets the quality standards for solid sel...

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Abstract

The invention discloses an oral solid self-emulsifying dispersoid for treating respiratory diseases of livestock and poultry. The oral solid self-emulsifying dispersoid is prepared from the followingactive pharmaceutical ingredients: 4 to 7 parts of volatile oil, 2 to 5 parts of emulsifying agents, 1 to 3 parts of co-emulsifying agents and 10 to 50 parts of solid dispersing agent carriers, wherein the volatile oil is prepared from fructus forsythiae oil, folium eucalypti oil, apricot kernel oil, radix platycodi oil and perilla seed oil through blending; the solid dispersing agent carriers arepolyethylene glycol. The pharmaceutical grade fructus forsythia oil, folium eucalypti oil, apricot kernel oil, radix platycodi oil and perilla seed oil are prepared into the volatile oil according toa certain proportion; the effective ingredients of the traditional Chinese medicine are fully utilized, and are combined with the emulsifying agents, the co-emulsifying agents and the solid dispersing agent carriers; the prepared finished product of the oral solid self-emulsifying dispersoid is pure natural and has no toxic and side effects; when the dispersoid is used for preventing and controlling the respiratory diseases of livestock and poultry, the stability of the volatile oil can be achieved; the medicine effect of the volatile oil is improved; the medicine resistance cannot occur; noresidue is left in livestock and poultry bodies; the harm to human bodies and environment is reduced; meanwhile, the production process is simple; the large-scale production is convenient.

Description

technical field [0001] The invention relates to traditional Chinese veterinary medicine technology, in particular to an oral solid self-emulsifying dispersion for treating respiratory diseases of livestock and poultry. Background technique [0002] Livestock and poultry respiratory diseases are syndromes caused by a variety of pathogens. They have the characteristics of rapid onset, rapid spread, long course of disease, high mortality, and difficult control. The clinical manifestations are panting, coughing, abdominal breathing and other respiratory symptoms. Respiratory diseases of livestock and poultry are the main diseases affecting the development of my country's aquaculture industry at present, often causing huge economic losses to the aquaculture industry. According to literature reports, the incidence of respiratory diseases in large-scale pig farms is generally between 30% and 60%, and the mortality rate is 5% to 30%. The incidence of respiratory diseases in chicken ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61K9/14A61K47/10A61P11/00
CPCA61K9/146A61K36/346A61K36/535A61K36/61A61K36/634A61K36/736A61K2300/00Y02A40/70
Inventor 叶兆伟赵存真张宇航吴海港张欢欢
Owner XINYANG AGRI & FORESTRY UNIV
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