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Method for preparing chitosan and abamectin suspension by using dispersion method

A technology of abamectin and chitosan, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve strong light sensitivity, reduce application effects, and instability of AVMs, etc. problem, to achieve the effect of overcoming instability and good release performance

Pending Publication Date: 2020-08-21
济宁润物生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this unique structure also causes abamectin to become an unstable substance, such as AVMs are unstable under acidic and alkaline conditions, sensitive to strong light, and easily form AVM isomers, which reduces its application effect , so designing stable formulations containing AVMs is of great significance for improving its application effect

Method used

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  • Method for preparing chitosan and abamectin suspension by using dispersion method
  • Method for preparing chitosan and abamectin suspension by using dispersion method
  • Method for preparing chitosan and abamectin suspension by using dispersion method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Concentration of chitosan solution (1g / L, A), quality of avermin (10mg, B), quality of Tween-80 (10mg, C), ultrasonic treatment (5min, D).

Embodiment 2

[0035] Concentration of chitosan solution (1.5g / L, A), quality of avermin (20mg, B), quality of Tween-80 (15mg, C), ultrasonic treatment (10min, D).

Embodiment 3

[0037] Concentration of chitosan solution (2g / L, A), quality of avermin (30mg, B), quality of Tween-80 (30mg, C), ultrasonic treatment (15min, D).

[0038] The experimental design of the above four factors A, B, C, and D is as follows:

[0039]

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Abstract

The invention relates to a preparation method of a suspension, in particular to a method for preparing a chitosan and abamectin suspension by using a dispersion method, which comprises the following steps: S1, measuring a proper amount of acetic acid to prepare a 1% acetic acid solution; S2, weighing a proper amount of chitosan into the acetic acid solution, and stirring to prepare a chitosan solution; S3, measuring a proper amount of tween-80 solution, and fixing the volume to 10ml by utilizing the purified water solution to prepare a dispersing agent solution; S4, mixing the prepared dispersing agent solution and chitosan solution into a container filled with abamectin, and carrying out ultrasonic treatment; S5, pouring the mixture subjected to ultrasonic treatment in the step S4 into ameasuring cylinder with a plug, adding purified water to a constant volume of 50ml, and uniformly shaking to obtain a chitosan and abamectin suspension; the prepared suspension has good release performance, and overcomes the defects of instability, easy photolysis and the like of abamectin in an acid-base environment, so that chitosan can be used as a novel pesticide candidate carrier.

Description

technical field [0001] The invention relates to a preparation method of a suspension, in particular to a method for preparing chitosan and abamectin suspensions by a dispersion method. Background technique [0002] Abamectins (AVMs) and their derivatives are effective nematicides that can kill a variety of nematodes and human parasites. The unique structure and unstable groups of AVM molecules promote the derivatization of AVM, making it a compound with strong anthelmintic activity (Köksal, 2015). However, this unique structure also causes abamectin to become an unstable substance, such as AVMs are unstable under acidic and alkaline conditions, sensitive to strong light, and easily form AVM isomers, which reduces its application effect , so the design of stable formulations containing AVMs is of great significance to improve its application effect. [0003] Chitosan is a modified biopolymer obtained by partial deacetylation of chitin. It is composed of (1→4) linked N-acety...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K47/36A61K47/26A61K31/7048A61P33/10
CPCA61K9/10A61K47/36A61K47/26A61K31/7048A61P33/10
Inventor 董学卫黄兆兴黄红香
Owner 济宁润物生物科技有限公司
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