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Microcapsule preparation for optimizing embedding

A technology of formulations and additives, applied in the field of performance-optimized microcapsule products, can solve the problems of overlapping layers, sudden release of core materials, and high content of surface core materials

Active Publication Date: 2016-05-11
INNOBIO CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the above materials, hot-melt fat and waxy materials are more widely used and safer than release materials with water or organic solvents as the medium, but there are still low proportions of microcapsule surface covering wall materials and high content of surface core materials , layer overlap, discontinuity and many other problems, resulting in serious product problems such as sudden release of core material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 350g of hydrogenated palm oil was heated and melted, and kept for 40 minutes. 350g of ascorbic acid is placed in the above solution and stirred until a stable homogeneous solution is formed, and the mixture is sprayed into cold air with a temperature of 10 degrees Celsius to form bead-shaped microcapsules through an atomizer, with an air volume of 260m 3 / h, atomization pressure 0.2MPa, flow rate 10ml / min, beads stay in the cold air for boiling operation time 20min to powder free flow, obtain slow-release product A, its content of ascorbic acid is 50.0%, and its content of surface active ingredient is 16.9% %, its hygroscopicity is 18.1%, and its first, 2, 3, 4, 5, 6, 8 hour release (pH6.8 phosphate buffer) is 23.5%, 26.7%, 30.1%, 35.2%, respectively. 36.9%, 38.2% and 43.2%.

Embodiment 2

[0034] 600g of hydrogenated palm oil and hydrogenated soybean oil (mass ratio 7:1) were heated and melted, and then 0.6 g of mono- and double-palmitin glycerides (mono-fatty acid glycerides: the mol ratio of di-fatty acid glycerides was 1:1.2) were added, and stirred until Dissolve completely and keep warm for 60min. 1400g beta-alanine is placed in the fluidized bed, and above-mentioned solution is sprayed into from the fluidized bed top with high-pressure pump. The air inlet temperature of the fluidized bed is 43°C, and the air volume is 20m 3 / h, atomization pressure 0.1MPa, flow rate 3ml / min, operating time 100min, obtain slow-release product B, its β-alanine content is 73.2%, its surface active component content is 12.3%, and its hygroscopicity is 8.9% , and its release rate (pH6.8 phosphate buffer) at 1, 2, 3, 4, 5, 6, and 8 hours was 19.7%, 23.5%, 27.5%, 30.0%, 35.2%, 37.6% and 42.4% respectively .

Embodiment 3

[0036] Heat and melt 1000g of hydrogenated palm oil and hydrogenated sunflower oil (mass ratio 2:1), then add 2g of monopalmitic acid glycerides (the molar ratio of monoglycerides: glycerides of fatty acids is 1:0.2), and stir until completely Dissolve and keep warm for 60min. 1400g beta-alanine is placed in the fluidized bed, and above-mentioned solution is sprayed into from the fluidized bed top with high-pressure pump. The air inlet temperature of the fluidized bed is 73°C, and the air volume is 50m 3 / h, atomization pressure 0.3MPa, flow rate 20ml / min, operating time 120min, obtain slow-release product C, its content of β-alanine is 60.7%, its surface active component content is 0.8%, and its hygroscopicity is 2.1%. , and its release rate (pH6.8 phosphate buffer) at 1, 2, 3, 4, 5, 6, and 8 hours was 5.6%, 2.8%, 5.6%, 8.4%, 11.2%, 16.8% and 17.9% respectively .

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Abstract

The invention provides a microcapsule preparation for optimizing embedding. The microcapsule preparation adopts a wall material and wall material assistant mixture as a release material, the wall material assistant comprises fatty acid-based C12-22 saturated or unsaturated fatty acid glyceride, and the fatty acid glyceride is fatty acid monoglyceride or fatty acid diglyceride or a mixture containing fatty acid monoglyceride and fatty acid diglyceride according to an arbitrary ratio. The microcapsule preparation using the fatty acid glyceride has an excellent embedding promotion effect, can effectively reduce the surface core material content, and optimizes the active substance release behavior.

Description

technical field [0001] The invention belongs to the technical field of microencapsulation, and in particular relates to performance-optimized microcapsule products. Background technique [0002] Sustained-release powders, microparticles, microcapsules, etc. made by microcapsule technology, in addition to obtaining stable, moisture-proof, taste-masking, and controlled-release characteristics, the product is almost the same as the raw material in particle size, and can be made into solid beverages, or directly Add it to liquids to make it easier to absorb and consume. In addition, it can also be flexibly made into tablets or capsules. Generally, the dosage of sustained-release preparations is smaller than that of ordinary preparations. For most drugs, it is easier to make sustained-release tablets to take, but for some nutrients with large doses, such as amino acids, plant extracts, etc., larger tablets And higher doses reduce compliance, and people prefer to make it into po...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/14A23P10/35
CPCA23V2002/00A61K9/5015A61K47/14A23V2200/224A23V2250/0604A23V2250/0606A23V2250/0612A23V2250/708A23V2250/704
Inventor 吴文忠陈剑彬李倩高盼李向成
Owner INNOBIO CORP LTD
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