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Drug for preventing and treating motion sickness and meniere disease and medical application of spirolactone

A technology for Meniere's disease and spironolactone, applied in the medical field, can solve problems such as increased expression, decreased expression of aquaporin 1, and hydrops in the membrane labyrinth, and achieves the effects of inhibiting the occurrence of motion sickness, inhibiting the progression of the disease course, and reducing pain.

Inactive Publication Date: 2020-08-25
NANTONG UNIVERSITY
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  • Abstract
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Problems solved by technology

In addition, it has also been found that intraperitoneal injection of aldosterone in the cochlea of ​​guinea pigs induces hydrops in the membranous labyrinth, and at the same time increases the expression of epithelial sodium channel (α-ENaC) protein and decreases the expression of aquaporin 1 (AQP1) in the cochlear tissue.

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  • Drug for preventing and treating motion sickness and meniere disease and medical application of spirolactone
  • Drug for preventing and treating motion sickness and meniere disease and medical application of spirolactone
  • Drug for preventing and treating motion sickness and meniere disease and medical application of spirolactone

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Embodiment Construction

[0025] The technical solutions of the present invention will be described in further detail below in conjunction with several preferred embodiments and accompanying drawings. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. It should be pointed out that the following examples are intended to facilitate the understanding of the present invention, but do not limit it in any way. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention. The test method that does not indicate specific conditions in the following examples usually follows conventional conditions.

[0026]The present invention uses spironolactone to antagonize the effect of rotational stimulation and elevated arginine vasopressin and mineralocorticoid aldosterone on the inner ear, reduces the sensitivity...

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Abstract

The invention relates to the technical field of medical treatment, in particular to a drug for preventing and treating a motion sickness and a meniere disease and a medical application of spirolactone. The drug comprises an effective dose of spirolactone for preventing and treating the motion sickness, wherein the drug is in a dose unit form; and the dosage of the spirolactone is 20-60 mg when anadult is injected with the spirolactone in a single dose. The drug can have an effective reference function in preventing and treating the motion sickness and the meniere disease, thereby further playing an effective drug role.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a medicine for preventing and treating motion sickness and Meniere's disease and the medical application of spironolactone. Background technique [0002] In 2003, my country's manned spaceflight achieved a breakthrough. In recent years, my country's transportation, ocean development, especially military navigation have developed rapidly, and the number of job opportunities and number of jobs in special environments has continued to increase. At the same time, with the improvement of living standards, people's travel times greatly increase. These factors lead to a significant increase in the number of cases of motion sickness, which brings pain and inconvenience to people's travel, and also affects the health, operation safety and navigation military operations of workers in special environments. [0003] When people take vehicles, ships, airplanes and other means of transportati...

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Application Information

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IPC IPC(8): A61K31/585A61P27/16A61P1/08
CPCA61K31/585A61P27/16A61P1/08
Inventor 姜正林周鑫张潇逸徐丽华刘贵珠
Owner NANTONG UNIVERSITY
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