Vaccine vector prepared based on anionic polymer and derivatives thereof
An anionic polymer and vaccine carrier technology, applied in the field of vaccine carrier and its preparation based on anionic polymer and its derivative materials, can solve the problem that it is difficult to make accurate evaluation of adjuvant effect, can not induce Th1 type immune response, Local adverse reactions hypersensitivity and other issues, to achieve the effect of simple and rapid preparation method, low toxicity and mild conditions
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Embodiment 1
[0072] Preparation of aluminum hydroxide nanoparticles based on γ-polyglutamic acid material: add 125μl 1mg / ml γ-polyglutamic acid to 345μl 80mmol / L Hepes buffer with pH 8 and mix well, and draw 550μl 1.76 mmol / L The aluminum sulfate solution of L is added to the above-mentioned solution, sonicated for 5 minutes, and the power is 120w, and it is obtained.
Embodiment 2
[0074] Preparation of aluminum hydroxide nanoparticles based on γ-polyglutamic acid material: add 120μl of 8mg / ml γ-polyglutamic acid to 360μl of 100mmol / L Hepes buffer with a pH of 8, mix well, and draw 555μl of 17.56 mmol / L The aluminum sulfate solution of L is added to the above solution, ultrasonicated for 10 minutes, and the power is 150w, and it is obtained.
Embodiment 3
[0076] Preparation of aluminum hydroxide nanoparticles-OVA based on γ-polyglutamic acid material: Add 130μl of 20mg / ml γ-polyglutamic acid to 370μl of 100mmol / L Hepes buffer with a pH of 8 and mix well, and 450μl of pipette 2.16 Mix the mmol / L aluminum sulfate solution and 100μl 4mg / ml OVA solution uniformly, add them to the above solution, sonicate for 8min, power 100w, and get it.
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